Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes.Actually, melanocytes are of neuroectodermal origin and then migrate extensively to reside throughout the body, including skin, uveal, mucosa, inner ear, and rectum, displaying as highly dendritic cells to manufacture melanin to defend against photodamage. Although the mortality rate of melanoma patients is prominently reduced in the past few decades due to early diagnosis, proper screening approaches, improved surgery principle and revolutionary advances of targeted therapy and immunotherapy, the prognosis of patients, in particular those with distant metastasis, remains un......2022-09-30

Sjögren's syndrome(SS)is a complex autoimmune rheumatic disease characterized by chronic inflammation of exocrine glands and the presence of autoantibodies against the ribonucleoprotein particles SSA/Ro and SSB/La. The clinical outcomes are dry eyes and dry mouth. Due to involvement of other organs, there are also several systemic manifestations of SS. The pathogenetic mechanism driving the disease has been poorly understood, although it may involve a combination of environmental and genetic factors. Because of the unknown etiology, only palliative treatment exists for SS, and many patients with SS experience a poor quality of life. A better understanding the pathophysiology is es......2022-09-23

On August 20, 2022, Juan Sastre, Department of Physiology, Faculty of Pharmacy, University of Valencia, Spain, and his team published a paper titled “p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3” in Redox Biology. They described a positive feedback between mitochondrial H2O2and p53 that downregulates sulfiredoxin and peroxiredoxin 3 leading to necroptosis in inflammation and obesity.The kits [ELISA Kit for High Mobility Group Protein 1 (HMGB1), SEA399Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution o......2022-09-23

Gastric ulcer (GU) is a major gastrointestinal disease caused by the imbalance between aggressive and defensive factors.Various factors such as pepsin, gastric acid, Helicobacter pylori(H. pylori), NSAIDs, prostaglandins, bicarbonate, and blood flow to mucosa play an important role in causing GU. Resistance to therapeutic drugs and limitations of traditional drug delivery methods limit the therapeutic effect of GU. In recent years, several research groups have reported various novel gastroretentive drug delivery systems, which will will be helpful in gastroretention of different dosage forms for treatment of GU.1. Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffecti......2022-09-20

On August 6, 2022,ZhengGuo, Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, PR China, and his team published a paper titled “Dynamic degradation patterns of porous polycaprolactone/β-tricalcium phosphate composites orchestrate macrophage responses and immunoregulatory bone regeneration” in Bioactive Materials. They established a steady in vitro degradation model to investigate the changes in the physio-chemical and biological properties of PT scaffolds during degradation.The kits [ELISA Kit for Interleukin 10 (IL10), SEA056Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Biodegradable polycaprolact......2022-09-15

Cardiomyopathy is a relatively rare and refractory myocardial disease caused by genetic and environmental factors.Cardiomyopathy is classified into dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, and unclassified cardiomyopathy. Major risk factors includes family history of cardiomyopathy, coronary heart disease, obesity, long term high blood pressure, alcoholism, chronic kidney disease and diabetes. Clarification of the genotype–phenotype correlation is needed to develop the precision medicine in cardiomyopathy. In addition, elucidation of the mechanisms involved in cardiomyopathy onset and progression......2022-09-09