Atopic dermatitis (AD) is a recurrent, chronic, non-infectious inflammatory dermatosis characterized by persistent itching of the skin. Theclinical picture includes eczema-like eruptions, such as erythema, papules, exudative lesions of a specific location, depending on the patient’s age andvarious skin degrees of dryness. The pathophysiology of atopic dermatitis is complex and multifactorial.Its understanding is complicated by the number of synergized factors that influence the disease. The most important are: genetic disorders, a defect in the epidermal barrier, an altered immune response and disturbed microbiological balance of the skin. In addition, environmental factors such as i......2022-08-26

On June 29, 2022,Zhao-Xiang Bian, School of Chinese Medicine, Hong Kong Baptist University, China, and his team published a paper titled “Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor” in Nature Communications. Their findings provided mechanistic insights into regulation of insulin sensitivity during physiological ageing and highlight MT1-MMP as a promising target for therapeutic avenue against diabetes.The kits [ELISA Kit for Matrix Metalloproteinase 14 (MMP14), SEC056Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Insulin sensitivity progressively declines with age. Currently, t......2022-08-24

Chimeric antigen receptor (CAR) Tcell immunotherapy refers to an adoptive immunotherapy that has rapidly developed in recent years. It is a novel type of treatment that enables T cells to express specific CARs on their surface, then returns these T cells to tumor patients to kill the corresponding tumor cells. CAR-T cell immunotherapy has demonstrated significant curative effects in the treatment of hematologic malignancies. These significant achievements promote its application in the treatment of solid tumors. In contrast with the therapeutic effect of CAR-T cell immunotherapy in hematological malignancies, the general curative effect on solid tumors is insignificant. Therefore, CAR-......2022-08-19

Neurodegenerative diseases are caused by the progressive loss of function or structure of nerve cells in the central nervous system. The most common neurodegenerative diseases include Alzheimer's disease(AD), Huntington's disease, motor neuron disease,and Parkinson's disease(PD). Although the physical or mental symptoms of neurodegenerative disease may be relieved by various treatment combinations, there are currently no strategies to directly slow or prevent neurodegeneration. Given the demographic evidence of a rapidly growing aging population and the associated prevalence of these common neurodegenerative diseases, it is paramount to develop safe and effective ways to pr......2022-08-12

In August 2022,Wanhai Xu, Department of Urology, the Fourth Hospital of Harbin Medical University, China, and his team published a paper titled “Bacteria-inspired transformable nanoparticle targets and covers residual tumor against bladder cancer recurrence” in Nano Today, which provided a promising intravesical treatment but also opportunities for clinical management on cancer recurrence.The kits [ELISA Kit for Fibronectin (FN), SEA037Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The regrowth of residual tumor left by incomplete surgery leads to bladder cancer recurrence. Postoperative intravesical instillation in clinic shows ......2022-08-10

Pancreatitis is a gastrointestinal disorder with considerable morbidity and mortality. Acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis form a disease continuum. Some factors causing these diseases include alcohol, bile acids, and ductal obstruction, where they induce the inflammatory response that promotes their pathogenesis. Common cellular events underlying the pathogenesis of acute pancreatitis include increased oxidative stress, premature intra-acinar trypsinogen activation, activated calcium signaling, mitochondrial dysfunction, endoplasmic reticulum stress, and autophagy impairment. Recently, several articles have reported new insights into the mechanis......2022-08-08