Schizophrenia is a severe psychiatric disorder with signs and symptoms that includehallucinations, delusions, disorganized speech and behaviour, diminished emotional expression, social withdrawal and cognitive impairment, typically manifests in late adolescence or early adulthood. Existing therapies largely address primarily positive symptoms (hallucinations and delusions), and the response to existing antipsychotic medications is highly variable, with approximately 30% of patients classified as treatment resistant. The lack of progress in therapeutic development is in part a consequence of the limited understanding of the molecular aetiology of psychiatric disorders.Recently, a number......2022-05-23

On 28 March 2022, Yunbing Wang, National Engineering Research Center for Biomaterials, Sichuan University, and his team published a paper tittled “A nitric oxide-eluting and REDV peptide-conjugated coating promotes vascular healing” in Biomaterials. They designed a bionic coating on vascular stents in a two-step manner to promote the healing of injured vessels by combining mussel-inspired molecular adhesion and a thiol-ene “click” reaction. The kits [ELISA Kit for Cyclic Guanosine Monophosphate (cGMP), CEA577Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Drug-eluting stents (DESs) placement remarkably reduces the over-prolife......2022-05-19

Alcohol-associated liver disease (ALD) is a leading cause of liver injury resulting from chronic and abusive alcohol consumption. The spectrum of ALD ranges from alcoholic steatosis, to hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). A wide variety of host and environmental factors and comorbidities have been shown to modify the development and progression of ALD, including age, sex, genetic factors, drinking pattern, obesity, and chronic viral hepatitis.Despite major advances made in identifying potential pathways and therapeutic targets, there is no effective therapy besides abstinence. Uncovering novel molecular mechanisms of ALD pathogenesis that can lead to new......2022-05-12

On 11 April 2022,Luoran Shang, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, and his team published a paper tittled “Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration” in Small, which proposed a lipopolysaccharide (LPS)-loaded photoresponsive cryogel porous microcarrier (CPM) for MSCs delivery and colonization to promote defect liver regeneration.The kits [ELISA Kit for Lipopolysaccharide (LPS), SEB526Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Mesenchymal stem cells (MSCs) have a demonstrated value for acute liver failure ......2022-05-11

On April 15, 2022, Fa-Xing Yu, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, and hia team published a paper tittled “WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy” in Molecular Cell, which uncovered a molecular mechanism underlying LATS1/2 regulation and provided a strategy for treating diverse malignancies related to Hippo pathway dysregulation.The proteins [Recombinant WW And C2 Domain Containing Protein 3 (WWC3), RPU918Hu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are ......2022-05-07

Atherosclerosisis the leading cause of cardiovascular diseases. Endothelial dysfunction and vascular inflammation are crucial in the initiation and progression of atherosclerosis. Atherosclerosisis initiated by endothelial cells(ECs) activation through modified lipids. Activated ECs release chemokines, which allow for the recruitment of immune cells into the subendothelial space called the intima. The recruited leukocytes produce inflammatory mediators, thus augmenting the ongoing chronic inflammatory process at arterial sites, orchestrating monocyte to macrophage differentiation, foam cell formation, migration, and proliferation of smooth muscle cells. As the disease progresses, the c......2022-05-05