On January 19, 2023,Tian Xue, CAS Key Laboratory of Brain Function and Disease, China, and his team published a paper titled “Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis” inCell. Their work unveiled a retina-supraoptic nucleus-brown adipose tissue axis that mediates the effect of light on glucose metabolism.The kits [ELISA Kit for Cholecystokinin (CCK), CEA802Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Public health studies indicate that artificial light is a high-risk factor for metabolic disorders. However, the neural mechanism underlying metabolic modulation by light remains elusive......2023-02-02

Acquired immunodeficiency syndrome (AIDS) is an infectious disease caused by human immunodeficiency virus (HIV) infection, which seriously endangers people’s health and lives. At present, the clinical treatment for AIDS is antiretroviral therapy (ART), which minimizes viral replication in patients and reduces plasma viral load to a level that cannot be detected by conventional testing methods. However, once the treatment is stopped, viral load will rebound to the pre-treatment level. An important reason why HIV is difficult to eliminate from the body is the long-term existence of HIV latent reservoir. The HIV latent virus reservoir composed of latently infected cells is a huge obstac......2023-01-16

On December 1, 2022, Teunis B. H. Geijtenbeek, Department of Experimental Immunology, Amsterdam UMC - location AMC, University of Amsterdam, The Netherlands, and his team published a paper titled “Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs” in nature immunology. They demonstrated that dectin-1 signaling in human DCs specifically instructed the differentiation of non-pathogenic IFN-γ-TH17 cells.The kits [ELISA Kit for Interferon Regulatory Factor 1 (IRF1), SEB564Hu; ELISA Kit for Interferon Regulatory Factor 5 (IRF5), SEB598Hu] of Cloud-Clone brand was chosed in this article, we are so proud fo......2023-01-10

Thrombosis- localized clotting of the blood -can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs. 1. Circadian nuclear receptor Rev-erbα is e......2023-01-09

On December 14, 2022, Zhenyu Zhong, Department of Immunology, University of Texas Southwestern Medical Center, USA, and his team published a paper titled “Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development” in Immunity. They fdemonstrated that impaired TREM2-dependent efferocytosis is a previously unrecognized key pathogenic event that licenses chronic liver inflammation to ultimately drive simple steatosis transition to nonalcoholic steatohepatitis (NASH).The kits [ELISA Kit for Sphingosine-1-Phosphate (S1P), CEG031Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserche......2023-01-06

Crohn’s disease is a chronic inflammatory condition that affects the gastrointestinal tract. It can cause lesions from mouth to anus and may result in extraintestinal complications.Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses. Thetherapies generally consist of steroids for rapid palliation of symptoms,monoclonal antibodies to IL-12/23 or integrin α4β7, immunomodulators, combination therapies, or surgery. However, these therapies may cause adverse reactions and have limited efficacy.Further exploration of the pathogenesis of Cro......2022-12-30