BRD4 is a transcriptional and epigenetic regulator that plays a pivotal role during embryogenesis and cancer development.As amember of the Bromodomains and Extraterminal (BET) family, BRD4 is characterized by two tandem bromodomains (BD1, BD2).BDs bind acetylated lysine residues on target proteins, including histones. Being itsaffinity higher for proteins with multiple acetylated residues, BRD4 interactswith hyper-acetylated histone regions along the chromatin, accumulating on transcriptionally active regulatory elements and promoting gene transcription both at initiation and elongation step.BRD4 and cancerNeuroblastoma (NB), a solid malignancy featured by rapid progression and high mo......2021-11-16

Journal：Journal of Cachexia, Sarcopenia and MuscleIF：12.910On September 18, 2021, Laurence Genton and his team from the Department of Nutrition at the University Hospital of Geneva, Switzerland, published a paper titled "Gut barrier and Microbiota Changes with Glycine and colon-chain amino acid Early Supplementation in Chronic Haemodialysis patients" on Journal of Cachexia,Sarcopenia and Muscle. To assess whether glycine or branched chain amino acid (BCAA) supplementation is associated with changes in intestinal barrier and microbiota in patients with chronic hemodialysis (HD).The ELISA Kits (ELISA Kit for Lipopolysaccharide (LPS), SEB526Hu) of Cloud-Clone brand was chose......2021-11-08

The cardiovascular system is composed of the heart and blood vessels. The heart sends blood to the arteries of the whole body, and exchanges nutrients, oxygen and metabolic waste through capillaries. After that, the blood enters the veins and is transported back to the heart by the veins of the whole body to complete the circulation. When the heart and its connected blood vessels appear pathological changes, it is called cardiovascular disease, including insufficient blood supply to the heart, arrhythmia, cardiac hypertrophy, cardiovascular disease, etc.,which can affect the function of the cardiovascular system.MacrophagesAs an important component of innate immunity, macrophages are w......2021-11-01

CD45 is expressed on all white blood cells and is called theleukocyte common antigen. CD45 is composed of a class of transmembrane proteins with similar structure and large molecular weight. Its cytoplasmic region acts as a protein tyrosine phosphatase, which can dephosphorylate and activate tyrosine on the substrate and play an important role in cell information transmission. As a key molecule of signal transduction on the cell membrane, CD45 plays an important role in development, maturation, function regulation and signal transmission of lymphocytes. In addition, according to the different types of CD45 molecule expressed by T cells, human T cells can be divided into CD45RA+ naive T......2021-10-27

CD25 is the α chain of IL-2R and a characteristic marker molecule on the surface of regulatory T (Treg) cells. Treg cells have immunosuppressive effects by inhibiting Th cells, CD8+T cell proliferation and activation, as well as NK cell-mediated killing activity. On the one hand, it can induce autoimmune tolerance, so as to maintain the stable state of the body and avoid the occurrence of autoimmune diseases; On the other hand, it can inhibit the formation and maintenance of tumor immune mechanism. Therefore, CD25 detection is of great significance in the prevention and treatment of autoimmune diseases and clinical tumors.2021-10-21

Pulmonary fibrosis (PF) is a major category of terminal changes of lung diseases characterized by proliferation of fibroblasts, accumulation of a large amount of extracellular matrix, accompanied by inflammatory damage and destruction of tissue structure, namely, structural abnormalities caused by abnormal repair of normal alveolar tissue after damage. The cause of most PF is unknown and is called idiopathic interstitial pneumonia. In idiopathic interstitial pneumonia, the most common disease type with PF lesions as the main manifestation is idiopathic PF, which is an interstitial lung disease that can lead to progressive loss of lung function.New progress in the research on the pathog......2021-10-19