On October 21, 2021, Miguel López, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Spain, and his team , published a paper titled "Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation" on Nature Metabolism, which underscored the potential of small extracellular vesicle (sEVs) to specifically target AMPK in hypothalamic neurons.The kits (ELISA Kit for Growth Differentiation Factor 15 (GDF15), SEC034Mu) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation......2021-12-14

Cytokeratin 19 (CK19) is mainly distributed in monolayer and pseudostratified epithelial cells, and is overexpressed in various epithelial tumor tissues. CK19 has great value in the diagnosis of lung cancer, especially the current preferred tumor marker for non-small cell lung cancer, with sensitivity up to 60% and specificity up to 95%. In addition, CK19 has a certain positive rate for other tumors, such as head and neck, breast, cervix, bladder and digestive tract tumors. Therefore, CK19 is of great significance for the early diagnosis, curative effect monitoring and prognosis of these cancers.2021-12-13

Tumor immunity is a process of immune response to the occurrence and development of tumors based on tumor antigenicity and immune function of the body.Antitumor immunotherapy is to stimulate and enhance the immune function of the body in order to control and kill tumor cells.Antitumor immunity improves the therapeutic effect of tumorRadiation therapy and chemotherapy are conventional treatments for cancer that have long been in use, but neither of these treatments can completely destroy tumor cells. The last surviving tumor cells need to be taken care of by the body's immune system. Therefore, it is of great significance to explore the mechanism of anti-tumor immunity in improving ......2021-12-10

Arginase (ARG) is an enzyme involved in the urea cycle, which catalyzes the hydrolysis of L-arginine into L-ornithine and urea.The content of ARG in liver isthe highest, followed by kidney, heart, spleen and skeletal muscle.ARG plays an important role in protecting cells from NH3 poisoning and cell growth and repair. In addition, studies have shown that the excessive activity of the ARG/ornithine pathway promotes cardiovascular and renal dysfunction and damage, and plays a role in the progression of central nervous system diseases and cancer. Therefore, ARG detection can help in the diagnosis and treatment of cardiovascular, renal and central nervous system diseases, as well as cancer.2021-12-07

Journal：nature communicationsIF：14.919On November11, 2021, Matthias Kettwig, Gogentine University Medical Center, Germany,and his team , published a paper titled "Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy" on Nature Communications, which suggested that RNaseT2-/-mice can be used to study central nervous system damage associated with RnaseT2 defects.The antibody (Polyclonal Antibody to Ribonuclease T2 (RNASET2), PAA113Mu01) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brainlesions, multifocal w......2021-12-06

Inflammatory arthritis, including spinal arthritis (SpA) and rheumatoid arthritis (RA), are a kind of chronic inflammatory diseases, which will gradually damage the joints of patients and have a negative impact on normal life.SpA is characterized by inflammation in distinct anatomical sites and abnormal new bone formation in the entheses of the spine and peripheral joints; RA is characterized by the production of autoantibodies against extracellular matrix proteins and other targets, synovial inflammation and hyperplasia, and progressive cartilage and bone erosion.New progress in inflammatory arthritis researchThe use of anti-inflammatory drugs, including biologics, may relieve inflamm......2021-12-01