Acute myeloid leukemia (AML) is a fatal form of hematopoietic malignancyby abnormal hematopoietic maturation, uncontrolled cellular proliferation,with 5-year survival rate of adult patients only 24%.Chemotherapy is standard-of-care, but therapeutic regimens have not changed dramatically in several decades and are often poorly tolerated.Despite the progress of therapeutic approaches such as allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chimeric antigen receptor (CAR) T cell treatment, the survival of AML patients has not been significantly improved. Novel treatments for AML are urgently needed. Therefore, further understanding of the pathogenesis of AML may contribu......2022-01-26

On December 1, 2021, Congwen Wei, Beijing Institute of Biotechnology, Academy of Military Medical Sciences, and his team published an article titled “GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity” in NATURE COMMUNICATIONS, which revealed a pathophysiological role of GP73 in triggering non-obese NAFLD.The kits [ELISA Kit for Apolipoprotein B (APOB), SEC003Mu；Polyclonal Antibody to Apolipoprotein B100 (APOB100), PAA603Mu01；ELISA Kit for Albumin (ALB), CEB028Mu；ELISA Kit for Apolipoprotein E (APOE), SEA704Mu；ELISA Kit for Apolipoprotein A1 (APOA1), SEA519Mu；ELISA Kit for Triglyceride (......2022-01-20

Metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), hyperlipidemia, and gout, have become major public health issues worldwide.Current therapy for metabolic diseases includes lifestyle interventions, balanced diet, appropriate exercise, and the use of pharmacological drugs. However, these drugs still have some limitations because of adverse effects.Targeting insulin resistance to treat metabolic diseasesInsulin resistance(IR) is a common pathophysiological condition in which patients present with reduced insulin sensitivity and thus glucose intolerance, andunable to obtain to process the required energy from glucose to maintain cellular metabolic......2022-01-17

On December 6, 2021, Li Tang, Institute of Materials Science and Engineering, École polytechnique fédérale de Lausanne (EPFL), and his team published an article titled “Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy”in Nature Biomedical Engineering, which revealed a mechanical immune checkpoint that could be targeted therapeutically to improve the effectiveness of cancer immunotherapies.The protein [Active Perforin 1 (PRF1), APB317Mu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Malignant transformation and tumour progression are associated with cancer-cell softening. Yet how the biomec......2022-01-12

Conventional chemotherapy and targeted therapy constitute an important part of first-line therapy for cancer management.Most patients with early-stage tumors achieve complete or partial response after chemotherapy and targeted therapy, while patients with advanced tumors often have poor treatment outcomes.Cancer cells evade the cytotoxicity of chemotherapy and targeted therapy through multifactorial intrinsic and acquired drug resistance mechanisms, and drug resistance is the main cause of chemotherapy failure.Study on drug resistance mechanism of tumor cellsThe development of drug resistance is a major challenge in cancer treatment. Adaptation in cancer therapy promotes drug resistanc......2022-01-10

On October 23, 2021, Weiming Tian, Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, and his team published an article titled "A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease" in Chemical Engineering Journal, which provided a potential early intervention strategy for retarding later AD progression.The antibody [Monoclonal Antibody to Hyaluronic Acid (HA), MAA182Ge21] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Neuroinflammation is one of the major proces......2022-01-06