On Mar 1, 2022, professor Qing Jiang from Nanjing Drum Tower Hospital published a paper titled Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression on Cell Metabolism.Hepatic osteodystrophy (HOD) is a metabolic bone disease that is often associated with chronic liver disease and is marked by bone loss. Here, we demonstrate that hepatic expression of the phosphatase PP2Acα is upregulated during HOD, leading to the downregulation of expression of the hepatokine lecithin-cholesterol acyltransferase (LCAT). Loss of LCAT function markedly exacerbates the bone loss phenotype of HOD in mice. In addition, we found that alterations in cholesterol levels are inv......2022-03-30

Sepsis, regarded as one of the oldest and most elusive syndromes in medicine, is a common condition in which tissues and organs are severely damaged due to a dysregulated host responses. Epidemiological data have shown that sepsis is a serious public health issue and may contribute to high morbidity and mortality worldwide, and this trend is increasing annually.New discovery on the mechanism of sepsisCurrently, the classical treatment of sepsis relies on appropriate antibiotics and steroid hormones to eradicate the source of infection as soon as possible, which is crucial for favorable outcome in sepsis.However, the precise temporal benefits of antibiotics may be controversial due to t......2022-03-25

Asthma is a heterogeneous disease, characterized by airway hyperresponsiveness, airway inflammation and reversible airway remodeling.As a common chronic respiratory disease, asthma remains a serious health problem that affects 358 million individuals, especially among children. Asthma patients report respiratory symptoms such as dyspnoea, wheeze, cough and/or chest tightness. These symptoms increase in frequency and intensity in more severe disease, accompanied by expiratory airflow limitation and an overall decline in lung function. Recent advances in the pathogenesis of asthmaThe exact triggers and underlying molecular mechanisms causing acute exacerbations remain poorly defined, alt......2022-03-18

On 17 February 2022, Bai Lu, School of Pharmaceutical Sciences, Tsinghua University, and his team published a paper tittled “TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice” in NATURE COMMUNICATIONS, which confirmed that TrkB agonist antibody can be used in the clinical treatment of premature ovarian failure.The kits [ELISA Kit for Estradiol (E2), CEA461Ge; ELISA Kit for Follicle Stimulating Hormone (FSH), CEA830Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Premature ovarian failure (POF) is a leading cause of women’s infertility without effective t......2022-03-17

2022-03-17

On 16 February 2022, Yuanyu Huang, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, and his team published a paper tittled “Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia” in SCIENCE ADVANCES, which established a thermostable clinically applicable delivery system for siRNA drug.The protein [Recombinant Calreticulin (CALR), RPB486Ra01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable cl......2022-03-10