Sepsis, regarded as one of the oldest and most elusive syndromes in medicine, is a common condition in which tissues and organs are severely damaged due to a dysregulated host responses. Epidemiological data have shown that sepsis is a serious public health issue and may contribute to high morbidity and mortality worldwide, and this trend is increasing annually.New discovery on the mechanism of sepsisCurrently, the classical treatment of sepsis relies on appropriate antibiotics and steroid hormones to eradicate the source of infection as soon as possible, which is crucial for favorable outcome in sepsis.However, the precise temporal benefits of antibiotics may be controversial due to t......2022-03-25

Asthma is a heterogeneous disease, characterized by airway hyperresponsiveness, airway inflammation and reversible airway remodeling.As a common chronic respiratory disease, asthma remains a serious health problem that affects 358 million individuals, especially among children. Asthma patients report respiratory symptoms such as dyspnoea, wheeze, cough and/or chest tightness. These symptoms increase in frequency and intensity in more severe disease, accompanied by expiratory airflow limitation and an overall decline in lung function. Recent advances in the pathogenesis of asthmaThe exact triggers and underlying molecular mechanisms causing acute exacerbations remain poorly defined, alt......2022-03-18

On 17 February 2022, Bai Lu, School of Pharmaceutical Sciences, Tsinghua University, and his team published a paper tittled “TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice” in NATURE COMMUNICATIONS, which confirmed that TrkB agonist antibody can be used in the clinical treatment of premature ovarian failure.The kits [ELISA Kit for Estradiol (E2), CEA461Ge; ELISA Kit for Follicle Stimulating Hormone (FSH), CEA830Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Premature ovarian failure (POF) is a leading cause of women’s infertility without effective t......2022-03-17

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On 16 February 2022, Yuanyu Huang, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, and his team published a paper tittled “Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia” in SCIENCE ADVANCES, which established a thermostable clinically applicable delivery system for siRNA drug.The protein [Recombinant Calreticulin (CALR), RPB486Ra01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable cl......2022-03-10

Lipopolysaccharide (LPS) is the component of the outer wall of gram-negative bacteria cell wall, and it consists of three components: lipid A, core polysaccharide and O-antigen.The lipid A of LPS enters the lipid layer as a component of the outer layer of the lipid bilayer, and the sugar chain is exposed outside the cell, and exists in this form on the cell surface of Gram-negative bacteria. LPS is difficult to come off the cell wall. When bacteria die, it will come off by dissolving and destroying cells, and exert its toxicity by acting on animal cells. Because of this nature, it is not a toxin secreted by bacteria outside the body (exotoxin), but a toxin that does not secrete, so it ......2022-03-10