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Recombinant Gremlin 1 (GREM1)

PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1

  • Product No.RPC128Hu02
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Predicted Molecular Mass21.9kDa
  • Accurate Molecular Mass25kDa(Analysis of differences refer to the manual)
  • Residues & TagsLys26~Asp184 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 97%
  • Isoelectric Point9.6
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 120  US$ 300  US$ 600  US$ 1800  US$ 4500 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Lung Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension PubMed: 25926293
Tumour Biol Overexpression of Gremlin promotes non-small cell lung cancer progression PubMed: 26392110
Int J Cardiol Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-term prognosis in suspected and proven acute heart failure patients PubMed: 26539964
International Journal of Cardiology Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-termprognosis in suspected and proven acute heart failure patients Pubmed:26539964
American Journal of Respiratory Cell and Molecular Biology BMPR2 Mutation-independent Mechanisms of Disrupted BMP Signaling in IPAH Pubmed:27187737
J Rheumatol GREM1 Is a Key ReCavia (Guinea pig )lator of Synoviocyte Hyperplasia and Invasiveness Pubmed:26834210
European cells & materials The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. pubmed:28266688
Sci Rep. Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. pubmed:28327551
American Journal of Respiratory Cell and Molecular Biology Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial … rcmb.2015-0402OC
Molecular Medicine Reports Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells pubmed:28260028
Cellular Haemostasis and Platelets Platelets as a novel source of Gremlin-1: Implications for thrombo inflammation pubmed:27929199
Scientific Reports Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis Pubmed: 31053735
International Journal of Molecular Sciences Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration Pubmed: 31878307
American Journal of Physiology-Cell Physiology Suppression of microRNA-23a/b-3p delays the development degenerative joint disease by activating Grem1 and TGF-β/Smad signaling pathway Pubmed: 32186934
Inflammopharmacology Protective role of microRNA-23a/b-3p inhibition against osteoarthritis through Gremlin1-depenent activation of TGF-β/smad signaling in chondrocytesa Pubmed:35441352
Mol Carcinog CAF‐derived exosomes transmitted Gremlin‐1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib Pubmed:35638711
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
APC128Hu02 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
RPC128Hu01 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
APC128Hu01 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
RPC128Hu02 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
PAC128Hu01 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
PAC128Hu02 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
LAC128Hu81 FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
LAC128Hu71 Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC.
MAC128Hu21 Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
MAC128Hu23 Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
RAC128Hu21 Recombinant Antibody to Gremlin 1 (GREM1) WB; IF; ICC; IHC; IP; FCM.
MAC128Hu22 Monoclonal Antibody to Gremlin 1 (GREM1) WB,IHC
SEC128Hu ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection.
LMC128Hu Multiplex Assay Kit for Gremlin 1 (GREM1) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.