Recombinant Gremlin 1 (GREM1)
PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1
- Product No.RPC128Hu01
- Organism SpeciesHomo sapiens (Human) Same name, Different species.
- SourceProkaryotic expression
- HostE.coli
- Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
- Subcellular LocationSecreted
- Predicted Molecular Mass24.9kDa
- Accurate Molecular Mass23kDa(Analysis of differences refer to the manual)
- Residues & TagsLys26~Asp184 with N-terminal His Tag
- Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.
- Traits Freeze-dried powder
- Purity> 97%
- Isoelectric Point9.0
-
Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein. - DownloadInstruction Manual
- UOM 10µg50µg 200µg 1mg 5mg
- FOB
US$ 120
For more details, please contact local distributors! US$ 300 US$ 600 US$ 1800 US$ 4500
SEQUENCE
![](/upload/product/pictures/RPC128Hu01-201711231108538330.jpg)
USAGE
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
GIVEAWAYS
INCREMENT SERVICES
-
Endotoxin Removal Kit
-
BCA Protein Quantification Kit
-
Protein Labeling Customized Service
-
Molecular Mass Marker for Protein
-
Recombinant Protein Customized Service
-
Monoclonal Antibody Customized Service
-
Polyclonal Antibody Customized Service
-
Protein Activity Test Experiment Service
-
Immunoprecipitation (IP) Experiment Service
-
Buffer
-
Endotoxin Removal Kit II
-
Real Time PCR Experimental Service
-
Spike RBD Protein (S-RBD)
-
Protein G
-
Protein A
Magazine | Citations |
Lung | Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension PubMed: 25926293 |
Tumour Biol | Overexpression of Gremlin promotes non-small cell lung cancer progression PubMed: 26392110 |
Int J Cardiol | Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-term prognosis in suspected and proven acute heart failure patients PubMed: 26539964 |
International Journal of Cardiology | Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-termprognosis in suspected and proven acute heart failure patients Pubmed:26539964 |
American Journal of Respiratory Cell and Molecular Biology | BMPR2 Mutation-independent Mechanisms of Disrupted BMP Signaling in IPAH Pubmed:27187737 |
J Rheumatol | GREM1 Is a Key ReCavia (Guinea pig )lator of Synoviocyte Hyperplasia and Invasiveness Pubmed:26834210 |
European cells & materials | The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. pubmed:28266688 |
Sci Rep. | Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. pubmed:28327551 |
American Journal of Respiratory Cell and Molecular Biology | Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial … rcmb.2015-0402OC |
Molecular Medicine Reports | Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells pubmed:28260028 |
Cellular Haemostasis and Platelets | Platelets as a novel source of Gremlin-1: Implications for thrombo inflammation pubmed:27929199 |
Scientific Reports | Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis Pubmed: 31053735 |
International Journal of Molecular Sciences | Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration Pubmed: 31878307 |
American Journal of Physiology-Cell Physiology | Suppression of microRNA-23a/b-3p delays the development degenerative joint disease by activating Grem1 and TGF-β/Smad signaling pathway Pubmed: 32186934 |
Inflammopharmacology | Protective role of microRNA-23a/b-3p inhibition against osteoarthritis through Gremlin1-depenent activation of TGF-β/smad signaling in chondrocytesa Pubmed:35441352 |
Mol Carcinog | CAF‐derived exosomes transmitted Gremlin‐1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib Pubmed:35638711 |
Catalog No. | Related products for research use of Homo sapiens (Human) Organism species | Applications (RESEARCH USE ONLY!) |
APC128Hu02 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. |
RPC128Hu01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APC128Hu01 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. |
RPC128Hu02 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
PAC128Hu01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
PAC128Hu02 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
LAC128Hu81 | FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IF. |
LAC128Hu71 | Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC. |
MAC128Hu21 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
MAC128Hu23 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
RAC128Hu21 | Recombinant Antibody to Gremlin 1 (GREM1) | WB; IF; ICC; IHC; IP; FCM. |
MAC128Hu22 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB,IHC |
SEC128Hu | ELISA Kit for Gremlin 1 (GREM1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
LMC128Hu | Multiplex Assay Kit for Gremlin 1 (GREM1) ,etc. by FLIA (Flow Luminescence Immunoassay) | FLIA Kit for Antigen Detection. |