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Recombinant Topoisomerase II (TOP2)

DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme

  • Product No.RPA792Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationNucleus
  • Predicted Molecular Mass32.1kDa
  • Accurate Molecular Mass40kDa(Analysis of differences refer to the manual)
  • Residues & TagsGly1079~Ser1328 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 97%
  • Isoelectric Point6.1
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 184  US$ 460  US$ 920  US$ 2760  US$ 6900 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Journal of Experimental & Clinical Cancer Research Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II pubmed:27852319
Bioorganic & Medicinal Chemistry Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. pubmed:28094224
European Journal of Medicinal Chemistry Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition Pubmed: 31884407
Int J Mol Sci 2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule Pubmed:35456915
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPA792Ra01 Recombinant Topoisomerase II (TOP2) Positive Control; Immunogen; SDS-PAGE; WB.
PAA792Ra01 Polyclonal Antibody to Topoisomerase II (TOP2) WB; IHC; ICC; IP.
MAA792Ra21 Monoclonal Antibody to Topoisomerase II (TOP2) WB; IHC; ICC; IP.
SEA792Ra ELISA Kit for Topoisomerase II (TOP2) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA792Ra Multiplex Assay Kit for Topoisomerase II (TOP2) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.