On October 24, 2022,Bo Peng, Department of Neurosurgery, Huashan Hospital, Fudan University, China, and his team published a paper titled “Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice” in Nature Communications. They elucidated the cellular and molecular mechanisms of microglial debris removal in mice, extending the knowledge on the maintenance of CNS homeostasis.The proteins [Recombinant Complement C4-B (C4B), RPB305Mu01; Recombinant Complement Component 4a (C4a), RPA389Mu01; Recombinant Complement Component 1, Q Subcomponent A (C1qA), RPD207Mu01; Recombinant Complement Component 3 (C3)......2022-12-30

Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli.Innate immune responses involving sensing of microbes and generation of antimicrobial effectors are the primary defense in response to pathogenic attacks and damage signals. Accumulating evidence suggests that multilayered molecular crosstalk between innate immune signaling and ......2022-12-26

On November 7, 2022,Shiming Yang, Department of Gastroenterology, Xinqiao Hospital, Army Medical University, China, and his team published a paper titled “Endoscopy Deliverable and Mushroom-Cap-Inspired Hyperboloid-Shaped Drug-Laden Bioadhesive Hydrogel for Stomach Perforation Repair” in ACS Nano. They demonstrated that the compressible hyperboloid-shaped gel could stably block the perforation and promoted wound healing during the 28 days of observation.The antibodies[Polyclonal Antibodyto Proliferating Cell Nuclear Antigen (PCNA), PAA591Mi01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Gastrointestinal tract perforation is a full......2022-12-22

Nowadays, human life expectancies are increasing, and studies on aging biology are looking to elucidate the biochemical and genetic processes that lead to aging over time and to find new strategies to counter this process. Aging is a process in which there is an irreversible and progressive decline of physiological functions; this loss could lead to the most important age-related diseases, such as cardiovascular diseases, musculoskeletal disorders and arthritis, neurodegenerative diseases, and cancer.Recently, a number of studies have reported that fecal microbes, blood, cerebrospinal fluid and other substances from young individuals can reverse aging in elderly individuals, which may ......2022-12-16

Prostate cancer(PCa)is the most frequent malignancy in the worldwide male population as well as one of the most common among all the leading cancer-related death causes. Although several men receive an early-stage disease diagnosis and run an indolent course, many cases are characterized by locally advanced or metastatic disease, at the time of diagnosis. Considering the worst course of the advanced disease, a hard challenge for clinicians has been to find a therapeutic approach for these patients in order to improve their prognosis as much as possible.Thus, further exploration of the mechanisms underlying PCa may facilitate the development of more effective therapies.1. A COP1-GATA2 a......2022-12-10

On October 24, 2022, Tiebang Kang, Sun Yat-sen University Cancer Center, China, and his team published a paper titled “Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity” in Cell Research. They reported that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical autophagy.The kits [High Sensitive ELISA Kit for Transmembrane Protein 173 (TMEM173), HEN011Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune ......2022-12-07