On October 14, 2022,Cui Hua Liu, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China, and his team published a paper titled “A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin” in Science. Their data reveal a role of the pathogen-derived phospholipid phosphatase in the regulation of GSDMD-dependent pyroptosis and cytokine releases, extending understanding of the elaborate regulatory mechanism of cellular inflammasome-pyroptosis signaling pathways during pathogen infection.The kits [ELISA Kit for Interferon Gamma (IFNg), SEA049Mu] of Cloud-Clone brand was chosed in this article,......2022-11-11

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)characterized by demyelination, axonal damage, and progressive neurologic disability.MS is a disease that affects brain, spinal cord and the optic nerves. The main symptoms include fatigue, tremor, motor dysfunction, nystagmus, numbness, loss of coordination or balance, disturbances in speech and vision, cognitive impairment and acute paralysis, and it is one of the most common neurological (non-traumatic) cause of disability in young adults. The etiology and pathogenesis of MS is complex and remain elusive, although both genetic and environmental factors are involved. Recently, several studies on the p......2022-11-04

On August 28, 2022, Sijin Liu, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, China, and his team published a paper titled “New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis” in Advanced Science. They found that a new compound can suppress iron-induced ferroptosis by modulating the intracellular signaling that drives lipid peroxidation. The kits [ELISA Kit for Beta-2-Microglobulin (b2M), SEA260Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Excess iron accumulation ......2022-11-03

T cell lineage is an important immune cell population, which is an essential component of the adaptive immune system. The ligation of the T cell receptor (TCR) by antigen/MHC complexes and the interaction of costimulation receptors regulate T cell activation. After stimulation, naïve T cells begin to proliferate and differentiate into highly specific effector T cells (Teff).Diverse T cell subsets serve different but specific functions in response to a wide variety of stimuli. T cell immunity plays a critical role in host defenses to pathogens and immune responses against neoplasm. During alloimmunity, T cells play a pivotal role for both, in tolerance and rejection. Therefore, the stu......2022-10-28

On Oct 15, 2022, professor Cui Hua Liu from CAS Key Laboratory of Pathogenic Microbiology and Immunology and professor Xiao Bo Qiu from China Pharmaceutical University published a paper titled A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin on Science. INTRODUCTION: Pyroptosis is a proinflammatory form of programmed cell death characterized by membrane pore formation thatallows the release of intracellular inflammatory mediators, a process that is elicited by the inflammasome-mediated cleavage and activation of gasdermin D (GSDMD). Growing evidence supports a critical role for pyroptosis in the control of infections by mammalian hosts, but how path......2022-10-27

Pulmonary arterial hypertension (PAH) is a fatal pulmonary vascular disease characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, culminating in right ventricular (RV) hypertrophy and failure.The dynamic vasoconstriction of pulmonary arteries, their adverse structural remodeling, fibrosis and stiffening, are the main causes of increased pulmonary vascular resistance. Besides this, endothelial dysfunction, an increase in inflammation, dysregulatedangiogenesis, metabolic disturbance, oxidative stress and mitochondrial dysregulation contribute to the progression of the disease. Current treatments improve quality of life and survival primarily by dilat......2022-10-21