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Recombinant Secreted Frizzled Related Protein 5 (SFRP5)
SARP3; Secreted Apoptosis Related Protein 3; Frizzled-related protein 1b
- Product No.RPC842Hu02
- Organism SpeciesHomo sapiens (Human) Same name, Different species.
- SourceProkaryotic expression
- HostE.coli
- Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
- Subcellular LocationSecreted
- Predicted Molecular Mass15.3kDa
- Accurate Molecular Mass18kDa(Analysis of differences refer to the manual)
- Residues & TagsCys181~Cys303 with N-terminal His Tag
- Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
- Traits Freeze-dried powder
- Purity> 90%
- Isoelectric Point9.5
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Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein. - DownloadInstruction Manual
- UOM 10µg50µg 200µg 1mg 5mg
- FOB
US$ 128
US$ 320
US$ 640
US$ 1920
US$ 4800
For more details, please contact local distributors!
SEQUENCE
USAGE
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
GIVEAWAYS
INCREMENT SERVICES
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Endotoxin Removal Kit
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BCA Protein Quantification Kit
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Protein Labeling Customized Service
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Molecular Mass Marker for Protein
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Recombinant Protein Customized Service
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Monoclonal Antibody Customized Service
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Polyclonal Antibody Customized Service
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Protein Activity Test Experiment Service
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Immunoprecipitation (IP) Experiment Service
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Buffer
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Endotoxin Removal Kit II
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Real Time PCR Experimental Service
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Spike RBD Protein (S-RBD)
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Protein G
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Protein A
| Magazine | Citations |
| Diabetes Research and Clinical Practice | Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance PubMed: 23290274 |
| European Journal of Clinical Investigation | Sfrp5 correlates with insulin resistance and oxidative stress PubMed: 23398169 |
| Pediatric Research | Balanced duo of anti-inflammatory SFRP5 and proinflammatory WNT5A in children Pubmed: 24603290 |
| Clin Endocrinol (Oxf). | SFRP5 correlates with obesity and metabolic syndrome and increases after weight loss in children Pubmed: 24330025 |
| The Journal of Clinical Endocrinology & Metabolism | Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans Pubmed: 23185036 |
| Atherosclerosis | Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease Pubmed: 24530778 |
| PLoS One. | Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation Pubmed:Pmc4072672 |
| J Clin Endocrinol Metab. | Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation Pubmed:24840810 |
| Oncology Letters | Serum secreted frizzled?related protein 5 levels differentially decrease in patients with hepatitis B virus?associated chronic infection and hepatocellular carcinoma Pubmed:25120720 |
| Diabetes Metab Res Rev. | Circulating SFRP5 levels are elevated in drug‐na?ve recently diagnosed type 2 diabetic patients as compared with prediabetic subjects and controls Pubmed:25139699 |
| Clinical & Experimental Immunology | The wingless-related integration site-5a/secreted frizzled-related protein-6 system is dysregulated in human sepsis Pubmed:25382802 |
| Diabetes Metab Res Rev | Circulating SFRP5 levels are elevated in drug-na PubMed: 25139699 |
| J Matern Fetal Neonatal Med | Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels PubMed: 26100762 |
| Eur J Clin Invest | Sfrp5 associates with beta-cell function in humans Pubmed:27019073 |
| Osteoporosis International | Bone marrow sFRP5 level is negatively associated with bone formation markers pubmed:27986984 |
| Diabetes/Metabolism Research and Reviews | Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults pubmed:28303637 |
| Cardiovascular Diabetology | Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 study pubmed:28851362 |
| Arteriosclerosis, Thrombosis, and Vascular Biology | Effect of SFRP5 (Secreted Frizzled–Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With … Pubmed:29674475 |
| Obesity | Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans Pubmed:29427376 |
| J Bas Res Med Sci | Decreased level of the anti-inflammatory adipokines, secreted frizzled-related protein 5 and adiponectin, in high cholesterol diet-induced atherosclerotic rats article-1-352-en.pdf |
| Molecular Biology Reports | The effect of serum and follicular fluid secreted frizzle-related protein-5 on in vitro fertilization outcomes in patients with polycystic ovary syndrome Pubmed: 30194556 |
| Macrophage LRP1 promotes diet-induced hepatic inflammation and metabolic dysfunction by modulating Wnt signaling | |
| British Journal Of Nutrition | A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile Pubmed: 30375290 |
| J Clin Endocrinol Metab | Role of wnt5a in Metabolic Inflammation in Humans Pubmed: 30137542 |
| Frontiers in Endocrinology | Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients Pubmed: 32300333 |
| CLINICAL BIOCHEMISTRY | Sfrp5/Wnt5a and Leptin/adiponectin levels in the serum and the periarterial adipose tissue of patients with peripheral arterial occlusive disease Pubmed: 33188773 |
| Sao Paulo Medical Journal | Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and … Pubmed: 32491086 |
| Kidney Blood Press Res | Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/β-Catenin Pathway 34469882 |
| Cytokine | Association of serum uromodulin with adipokines in dependence of type 2 diabetes 34920231 |
| PLoS One | Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study Pubmed:34990470 |
| JMIR Res Protoc | Investigating New Sensory Methods Related to Taste Sensitivity, Preferences, and Diet of Mother-Infant Pairs and Their Relationship With Body Composition … Pubmed:35475790 |
| Diabetology | Early Pregnancy Serum Concentration of Secreted Frizzled-Related Protein 4, Secreted Frizzled-Related Protein 5, and Chemerin in Obese Women Who Develop … |