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Recombinant Neuregulin 1 (NRG1)

ARIA; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

  • Product No.RPB866Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane, Secreted
  • Predicted Molecular Mass15.7kDa
  • Accurate Molecular Mass20/18kDa(Analysis of differences refer to the manual)
  • Residues & TagsThr264~Gly393 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point9.3
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 144  US$ 360  US$ 720  US$ 2160  US$ 5400 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Neuroscience Letter Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrom Cyagen: source
PLoS One. ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis PubMed: PMC3519469
The Journal of Clinical Investigation Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration PubMed: PMC3428100
Physiol Behav Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress PubMed: 26626816
J Toxicol Sci.  Effects of prolonged antipsychotic administration on neureCavia (Guinea pig )lin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect. Pubmed:26961615
journal of cellular and molecular medicine Qiliqiangxin protects against anoxic injury in cardiac microvascular endothelial cells via NRG-1/ErbB-PI3K/Akt/mTOR pathway. pubmed:28271613
Transl Psychiatry. Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation. pubmed:28267150
Human Molecular Genetics A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas Pubmed: 30335132
Aging (Albany NY) Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin Pubmed: 32920546
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPB866Ra01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB866Ra02 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB866Ra03 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB866Ra04 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
PAB866Ra02 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAB866Ra03 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAB866Ra01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAB866Ra04 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
LAB866Ra71 Biotin-Linked Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC.
SEB866Ra ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection.
WEB866Ra Wide-range ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection.
LMB866Ra Multiplex Assay Kit for Neuregulin 1 (NRG1) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.