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Recombinant Calcitonin Gene Related Peptide (CGRP)

CALCB; CGRP2; CALC2; CGRP-II; Calcitonin Gene Related Peptide 2; Calcitonin 2; Calcitonin Related Polypeptide Beta

  • Product No.RPA876Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Predicted Molecular Mass15.0kDa
  • Accurate Molecular Mass19kDa(Analysis of differences refer to the manual)
  • Residues & TagsMet1~Ala127 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point9.9
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 144  US$ 360  US$ 720  US$ 2160  US$ 5400 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Evidence-Based Complementary and Alternative Medicine Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Hindawi: 190370
The Journal of Headache and Pain Increased levels of CGRP in peripheral blood in women with chronic migraine: A reliable biological marker PubMed: PMC3620076
Headache: The Journal of Head and Face Pain CGRP and VIP Levels as Predictors of Efficacy of Onabotulinumtoxin Type A in Chronic Migraine Onlinelibrary: head.12372
PLoS One. Ultraviolet B Irradiation Reduces the Expression of Adiponectin in Ovarial Adipose Tissues through Endocrine Actions of Calcitonin Gene-Related Peptide-Induced Serum Amyloid A Pubmed:Pmc4028234
Int J Vasc Med. Prognostic significance of circulating and endothelial progenitor cell markers in type 2 diabetic foot. Pubmed:24624298
Arch Gynecol Obstet. Calcitonin gene-and parathyroid hormone-related peptides in normotensive and preeclamptic pregnancies: a nested case–control study Pubmed:24943060
Pain OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine PubMed: 25735000
Molecular Medicine Reports Exogenous α-calcitonin gene-related peptide attenuates lipopolysaccharide-induced acute lung injury in rats PubMed: 25892548
Annals of Allergy, Asthma and Immunology Effect of acupuncture on house dust mite specific IgE, substance P, and symptoms in persistent allergic rhinitis Pubmed:27156748
Cephalalgia. Relationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients Pubmed:27250233
Cardiology.  Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction. Pubmed:27144592
J Headache Pain Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB Pubmed:27150105
Frontiers in Physiology Prevention of Bone Loss in a Model of Postmenopausal Osteoporosis throughAdrenomedullin Inhibition. pubmed:27445864
Naunyn Schmiedebergs Arch Pharmacol. Opioid receptor agonists may favorably affect bone mechanical properties in rats with estrogen deficiency-induced osteoporosis. pubmed:27896372
American Journal of Translational Research A new comorbidity model and the common pathological mechanisms of migraine and epilepsy pubmed:28559979
9 Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome pubmed:28483500
Journal of Clinical Investigation CNS myeloid cells critically regulate heat hyperalgesia Pubmed:29634489
Journal of Headache and Pain Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal Pubmed:30006780
BioRxiv - the preprint server for biology RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis 10.1101:357582
International Journal of Pharmaceutical Sciences and Research MOTION SICKNESS INDUCES PHYSIOLOGICAL AND NEURONAL ALTERATIONS IN MOUSE MODEL
JOURNAL OF PERIODONTOLOGY Periodontal inflammation is related to increased serum calcitonin gene‐related peptide (CGRP) levels in patients with chronic migraine Pubmed: 31070784
Molecular and Cellular Biochemistry Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling Pubmed: 31420791
Journal of Headache and Pain Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q-and T-type Ca 2+ currents in rat trigeminal ganglion …
Respiratory Physiology & Neurobiology Effects of nanoparticles on Neuroinflammation in a Mouse Model of Asthma Pubmed: 31542455
Europe PMC Electrical stimulation of the superior sagittal sinus suppresses A-type K currents and increases P/Q-and T-type Ca 2 currents in rat trigeminal ganglion … Pubmed: 31375062
Clinical Chemistry and Laboratory Medicine Effects of endurance exercise on serum concentration of calcitonin gene-related peptide (CGRP): a potential link between exercise intensity and headache Pubmed: 32286239
MOLECULAR BIOLOGY REPORTS Serum CGRP, VIP, and PACAP usefulness in migraine: a case–control study in chronic migraine patients in real clinical practice Pubmed: 32951099
Scientific Reports Mild systemic inflammation enhances response to OnabotulinumtoxinA in chronic migraineurs 33441852
Nature Communications Perirenal adipose afferent nerves sustain pathological high blood pressure in rats Pubmed:35668093
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPA876Hu01 Recombinant Calcitonin Gene Related Peptide (CGRP) Positive Control; Immunogen; SDS-PAGE; WB.
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LAA876Hu71 Biotin-Linked Polyclonal Antibody to Calcitonin Gene Related Peptide (CGRP) WB; IHC; ICC.
MAA876Hu22 Monoclonal Antibody to Calcitonin Gene Related Peptide (CGRP) WB; IHC; ICC; IP.
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LMA876Hu Multiplex Assay Kit for Calcitonin Gene Related Peptide (CGRP) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.
KSA876Hu11 ELISA Kit DIY Materials for Calcitonin Gene Related Peptide (CGRP) Main materials for "Do It (ELISA Kit) Yourself".