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Recombinant Interleukin 17 (IL17)

IL17A; CTLA8; IL-17A; Cytotoxic T-Lymphocyte-Associated Protein 8

  • Product No.RPA063Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1μg (determined by the LAL method).
  • Subcellular LocationSecreted
  • Predicted Molecular Mass18.7kDa
  • Accurate Molecular Mass18kDa(Analysis of differences refer to the manual)
  • Residues & TagsAla18~Ser150 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point9.0
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 172  US$ 430  US$ 860  US$ 2580  US$ 6450 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
PLOS ONE Impaired Autoimmune T Helper 17 Cell Responses Following DNA Vaccination against Rat Experimental Autoimmune Encephalomyelitis PubMed: PMC2577303
Cellular Immunology Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells ScienceDirect: S0008874911002164
The Journal of Urology Improvement by Phytotherapeutic Agent of Detrusor Overactivity, Down-Regulation of Pharmacological Receptors and Urinary Cytokines in Rats with Cyclophosphamide Induced Cystitis PubMed: S0022534712049087
Critical Care Medicine Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhage PubMed: PMC3383056
Lower Urinary Tract Symptoms Effects of Saw Palmetto Extract on Urodynamic Parameters, Bladder Muscarinic and Purinergic Receptors and Urinary Cytokines in Rats with Cyclophosphamide-Induced Cystitis Onlinelibrary: luts.12015
Shock Expression of Hemopexin in Acute Rejection of Rat Liver Allograft Identified by Serum Proteomic Analysis. Lww: Source
J Vet Med Sci. CD4+ T Cell Cytokine Gene and Protein Expression in Duodenal Mucosa of Dogs with Inflammatory Bowel Disease Pubmed:24270804
Journal of Dairy Science Increased blood-circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosis Pubmed:24679935
Inflammation.? Pemetrexed Ameliorates Experimental Arthritis in Rats Pubmed:25129058
Inflammation Lapatinib Ameliorates Experimental Arthritis in Rats Pubmed:25283886
Molecular and Cellular Biochemistry Beta-arrestin-2 negatively modulates inflammation response in mouse chondrocytes induced by 4-mer hyaluronan oligosaccharide Pubmed:25318610
Molecular Medicine Reports Function of interleukin?17 and ?35 in the blood of patients with hepatitis B?related liver cirrhosis Pubmed:25323532
Genet Mol Res Protective effect and mechanism of probucol in the treatment of spinal cord injury PubMed: 26214485
veterinary research forum Evaluation of proliferation and cytokines production by mitogen-stimulated bovine peripheral blood mononuclear cells Article_14936_6.Html:
Tumor Biology Hypoxia-induced secretion of IL-20 from adipose-derived mesenchymal stem cell promotes growth and cancer stem cell properties of Burkitt lymphoma PubMed: 26695151
Clinical & Experimental Immunology MicroRNA‐155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th18) cells PubMed: 25761610
J Reprod Immunol The immunomodulating effect of seminal plasma on T cells PubMed: 25799173
Biomarkers Interleukin-17 levels correlate with poor prognosis and vascular endothelial growth factor concentration in the serum of patients with non-small cell lung cancer PubMed: 26301881
Molecular Medicine Reports Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats Pubmed:27357729
SpringerPlus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression ofHMGB1/RAGE/NF-ΚB pathway. Pubmed:27026909
International Immunopharmacology Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery Pubmed:26802602
Journal of Agricultural Biotechnology Gln Attenuates LPS-induced Inflammatory Injury of Bos taurus Testis Sustentacular Cells 10610
Veterinary Research Communications Immunological and pathological investigations in equine experimental uveitis pubmed:27344152
Journal of Neuroinflammation Th17-skewed immune response and cluster of differentiation 40 ligand expression in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis. pubmed:28114998
American Journal of Translational Research Anti-inflammatory effects of Boletus edulis polysaccharide on asthma pathology pubmed:27830033
Springerplus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway pubmed:27026909
Journal of Virology Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized inPlasma and Milk in Chronically Infected African Green Monkeys. pubmed:
J Nephropathol Relationship between IL-17 serum level and ambulatory blood pressure in women with polycystic ovary syndrome pubmed:28042549
Journal of Nephropathology Relationship between IL-17 and ambulatory blood pressure in polycystic ovary syndrome 8b168a09f5832df1b5c2f48631612458b2d8.pdf
Basic Clin Pharmacol Toxicol. Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. pubmed:28032440
Gut Pathog. Oral administration of Clostridium butyricum CGMCC0313‐1 reduces ovalbumin‐induced allergic airway inflammation in mice pubmed:28250847
Procalcitonin und proinflammatorische Zytokine in der bronchoalveolären Lavage beim lungenkranken Pferd unter inhalativer Glukokortikoidtherapie FUDISS_thesis_000000103830
Scientific Report Anti-asthmatic efect of pitavastatin through aerosol inhalation is associated with CD4+ CD25+ Foxp3+ T cells in an asthma mouse model pubmed:28729731
Basic & Clinical Pharmacology & Toxicology Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4 + T Helper 17(Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling doi:10.1111
Academic Journal Antiinflammatory and antioxidant effects of gemcitabine in collagen-induced arthritis model pubmed:28618762
International Journal of Clinical and Experimental Pathology Low-density neutrophils in severe fever with thrombocytopenia syndrome (SFTS) display decreased function to phagocytose SFTS virus and enhanced capacity to synthesize cytokines ISSN:1936-2625/IJCEP0045334
Asian Pacific Society of Respirology Oral administration of Clostridium butyricum CGMCC0313-1 reduces ovalbumin-induced allergic airway inflammation in mice pubmed:28122397
MYOPAIN Increased Levels of IL-17, IL-23, MIP-1α, MCP-1 and Global Leukocytes in Fibromyalgia Patients 10.1080/24708593.2017.1357664
Molecular Medicine Reports Lower level of IL‑35 and its reduced inhibition in Th17 cells in patients with bone marrow mononuclear cells Coombs test‑positive hemocytopenia. pubmed:29257310
Molecular Medicine Reports Interleukin-17 antagonist attenuates lung inflammation through inhibition of the ERK1/2 and NF-κB pathway in LPS-induced acute lung injury 10.3892/mmr.2017.6837
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY  Dexamethasone reduces serum level of IL-17 in Bleomycin-A5-induced rats model of pulmonary fibrosis pubmed:28608724
International Immunopharmacology Therapeutic effect of bone marrow mesenchymal stem cells pretreated with acetylsalicylic acid on experimental periodontitis in rats pubmed:29195233
Biomedical Research Associations among interleukin-17, interferon-gamma, and acute coronary syndrome ISSN 0970-938X
Cellular Physiology and Biochemistry Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory … Pubmed:29672286
Frontiers in Pharmacology Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal … Pubmed:29375374
Bioscience Reports Decreased miR-128 expression alleviated the progression of Rheumatoid arthritis by up-regulating the expression of TNFAIP3 Pubmed:29853534
Medical Science Monitor Involvement of T-Helper 9 Activation in a Mouse Model of Allergic Rhinitis Pubmed:29982264
Journal of International Medical Research Changes in Th1/Th2-producing cytokines during acute exacerbation chronic obstructive pulmonary disease Pubmed:29950127
Canadian Journal of Physiology and Pharmacology Inhibition of microRNA-155 attenuates concanavalin A-induced autoimmune hepatitis by regulating Treg/Th17 cell differentiation Pubmed: 30290123
BMC Microbiology Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal … Pubmed: 30359236
Biology of Reproduction Recombinant adiponectin alleviates abortion in mice by regulating Th17/Treg imbalance via p38MAPK-STAT5 pathway Pubmed: 30496353
BMC MICROBIOLOGY Enhanced antifungal activity of bovine lactoferrin-producing probiotic Lactobacillus casei in the murine model of vulvovaginal candidiasis Pubmed: 30621597
CNS Neuroscience & Therapeutics Negative regulation of glial Tim‐3 inhibits the secretion of inflammatory factors and modulates microglia to antiinflammatory phenotype after experimental intracerebral?… Pubmed: 30677253
OPEN ACCESS MACEDONIAN JOURNAL OF MEDICAL SCIENCES Seluang Fish (Rasbora Spp.) Oil Decreases Inflammatory Cytokines Via Increasing Vitamin D Level in Systemic Lupus Erythematosus
Frontiers in Microbiology Local probiotic Lactobacillus crispatus and Lactobacillus delbrueckii exhibit strong antifungal effects against vulvovaginal candidiasis in a rat model
中国免疫学杂志 TRAF-6 调控TGF-β1-Smad2/Smad3 信号通路在Graves 病免疫发病机制中的作用
Microbial Pathogenesis Therapeutic effectiveness of type I interferon in vulvovaginal candidiasis Pubmed: 31158491
Inflammation Protein Kinase C Theta Inhibition Attenuates Lipopolysaccharide-Induced Acute Lung Injury through Notch Signaling Pathway via Suppressing Th17 Cell Response … Pubmed: 31297750
international immunopharmacology Adenovirus-mediated down-regulation of miR-21-5p alleviates experimental autoimmune uveoretinitis in mice Pubmed: 31228813
Untersuchung einer Th17-vermittelten Immunantwort bei der kaninen idiopathischen Epilepsie
Free Radical Biology and Medicine Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat Pubmed: 31255668
BioMed Research International Indoleamine 2, 3-Dioxygenase (IDO) Regulates Th17/Treg Immunity in Experimental IgA Nephropathy
Animals Anti-Inflammatory State in Arabian Horses Introduced to the Endurance Training Pubmed: 31462005
World Journal of Pediatrics Regulation of JAK/STAT signal pathway by miR-21 in the pathogenesis of juvenile idiopathic arthritis Pubmed: 31641939
Biotechnology and Applied Biochemistry Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf‐2, HO‐1 and cytokine levels in an experimental arthritis model Pubmed: 31746064
Microbial Pathogenesis Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice Pubmed: 31676364
International Journal of Rheumatic Diseases Effects of thalidomide on Th17, Treg cells and TGF‐β1/Smad3 pathway in a mouse model of systemic sclerosis Pubmed: 31840939
Cytokine Levels of pro-and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis Pubmed: 31927460
international urology and nephrology The therapeutic effect of dendritic cells expressing indoleamine 2, 3-dioxygenase (IDO) on an IgA nephropathy mouse model Pubmed: 31894556
JOURNAL OF PERIODONTAL RESEARCH Salivary Del‐1, IL‐17, and LFA‐1 levels in periodontal health and disease Pubmed: 32153040
journal of molecular endocrinology LncRNA Profile in Hashimoto's Thyroiditis and Potential Function of NONHSAT079547. 2 Pubmed: 32229697
Toxicol Appl Pharmacol Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling Pubmed: 33171191
CARDIOVASCULAR DRUGS AND THERAPY Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway Pubmed: 32946036
Biomed Research International Effects of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis Pubmed: 32908870
J Neurosurg Covering the proximal nerve stump with chondroitin sulfate proteoglycans prevents traumatic painful neuroma formation by blocking axon regeneration after … Pubmed: 32470939
JOURNAL OF MICROBIOLOGY Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice Pubmed: 32424577
bioscience reports Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic rhinitis in rat Pubmed: 32395767
Journal of Biochemical and Molecular Toxicology Vitamin D3 and calcium cosupplementation alleviates cadmium hepatotoxicity in the rat: Enhanced antioxidative and anti‐inflammatory actions by remodeling cellular …
Revista da Associacao Medica Brasileira A comparison of IL-17 and IL-34 concentrations in the cerebrospinal fluid of patients with acute inflammatory demyelinating neuropathy and chronic …
biosciences biotechnology research asia Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet.
ACS Biomaterials Science & Engineering Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction
Effects of minocycline on neuroinflammation, gut microbiome and hippocampal neurogenesis in rats with Gulf War Illness
Minocycline Alleviate A Rat Model Of Gulf War Illness Via Altering Gut Microbiome, Attenuating Neuroinflammation And Enhancing Hippocampal Neurogenesis
中国应用生理学杂志 丹参对非酒精性脂肪肝Th17细胞及相关细胞因子的影响*
Rev Assoc Med Bras A comparison of IL-17 and IL-34 concentrations in the cerebrospinal fluid of patients with acute inflammatory demyelinating neuropathy and chronic?¡­ 33295414
BEHAVIOURAL BRAIN RESEARCH Minocycline alleviates Gulf War Illness rats via altering gut microbiome, attenuating neuroinflammation and enhancing hippocampal neurogenesis 34000339
Int J Clin Pract Serum Galectin©\3 Levels in Patients with Psoriasis 34137138
cells The Effect of the Clenbuterol¡ª¦Â2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen?¡­ 33920705
Mediators of Inflammation Sparstolonin B Exerts Therapeutic Effects on Collagen-Induced Arthritis by Inhibiting the NLRP3 Inflammasome and Reducing the Activity of ¦Á1, 3 ¡­
CNS Neurosci Ther Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke 34591349
PLoS One Evaluation of the involvement of Th17-cells in the pathogenesis of canine spinal cord injury 34591917
J Periodontol Cytokine profile in serum and gingival crevicular fluid of children with inflammatory bowel disease: A case‐control study 34730850
Transl Psychiatry Associations between expression of indoleamine 2, 3-dioxygenase enzyme and inflammatory cytokines in patients with first-episode drug-naive … 34802039
Viruses Interleukin-10-Mediated Lymphopenia Caused by Acute Infection with Foot-and-Mouth Disease Virus in Mice 34960627
PLoS One Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy Pubmed:35025939
Pathogens Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients Pubmed:35056005
Biomed Pharmacother Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis Pubmed:35453007
npj Biofilms and Microbiomes The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal Pubmed:35379849
Expert Opinion on Therapeutic Targets Dapagliflozin mitigates ovalbumin-prompted airway inflammatory-oxidative successions and associated bronchospasm in a rat model of allergic asthma Pubmed:35549595
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPA063Ra01 Recombinant Interleukin 17 (IL17) Positive Control; Immunogen; SDS-PAGE; WB.
PAA063Ra01 Polyclonal Antibody to Interleukin 17 (IL17) WB; IHC; ICC; IP.
MAA063Ra22 Monoclonal Antibody to Interleukin 17 (IL17) WB; IHC; ICC; IP.
MAA063Ra23 Monoclonal Antibody to Interleukin 17 (IL17) WB; IHC; ICC; IP.
MAA063Ra21 Monoclonal Antibody to Interleukin 17 (IL17) WB; IHC; ICC; IP.
SEA063Ra ELISA Kit for Interleukin 17 (IL17) Enzyme-linked immunosorbent assay for Antigen Detection.
MEA063Ra Mini Samples ELISA Kit for Interleukin 17 (IL17) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA063Ra Multiplex Assay Kit for Interleukin 17 (IL17) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.