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Cartilage Oligomeric Matrix Protein (COMP)

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MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5

Cartilage Oligomeric Matrix Protein (COMP)
CCC B197
HGNC 2227
MGI 88469
PubMed 18855621
RGD 2378
UniProt P49747
Wiki COMP

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix proteins. The protein consists of five 87-kDa subunits held together by interchain disulfide bonds, forming a 435-kDa pentameric protein. COMP is expressed in all types of cartilage, vitreous of the eye, tendon, and vascular smooth muscle cells.

Immunohistological staining of articular cartilage has revealed a developmentally regulated localization of COMP to the chondrocyte territorial and interterritorial matrix. COMP binds in a zinc-dependent manner to collagen type I and type II and also to collagen type IX. The thrombospondin family currently includes five members: TSP-1, TSP-2, TSP-3, TSP-4, and COMP (also referred to as TSP-5).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Hu01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Hu01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB
MAB197Hu22 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
Assay Kits SEB197Hu ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB197Hu CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Mu01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu02 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu03 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Mu04 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Mu01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu02 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu04 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Mu03 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
LAB197Mu71 Biotin-Linked Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC.
MAB197Mu21 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
MAB197Mu22 Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB.
Assay Kits SEB197Mu ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB197Ra01 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Ra02 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB197Ra03 Recombinant Cartilage Oligomeric Matrix Protein (COMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB197Ra01 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
PAB197Ra02 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
LAB197Ra71 Biotin-Linked Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC.
PAB197Ra03 Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) WB; IHC; ICC; IP.
Assay Kits SEB197Ra ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB197Ra CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits SEB197Ca ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cartilage Oligomeric Matrix Protein (COMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Oligomeric Matrix Protein (COMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Oligomeric Matrix Protein (COMP) Polyclonal Antibody Customized Service Offer
Assay Kits SEB197Eq ELISA Kit for Cartilage Oligomeric Matrix Protein (COMP) Enzyme-linked immunosorbent assay for Antigen Detection.
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  19. "Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein."Clin. Genet. 51:219-224(1997) [PubMed] [Europe PMC] [Abstract]
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  22. "Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia."Hum. Mutat. Suppl. 1:S10-S17(1998) [PubMed] [Europe PMC] [Abstract]
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  26. "A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity."Am. J. Hum. Genet. 69:969-980(2001) [PubMed] [Europe PMC] [Abstract]
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