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Insulin Like Growth Factor Binding Protein 2 (IGFBP2)

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IBP2; IGF-BP53

Insulin Like Growth Factor Binding Protein 2 (IGFBP2)
CCC A053
HGNC 5471
MGI 96437
PubMed 20074524
RGD 2873
UniProt P18065
Wiki IGFBP2

Insulin-like growth factor binding protein-2 (IGFBP-2) is one of six characterized IGFBPs which specifically bind and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I, suggesting a role in regulation of IGF-II action. Studies in the fetal sheep indicate that IGFBP-2 is produced in many tissues, apparently coincident with IGF-II expression.

Recent studies of serum IGFBP-2 levels have shown that, unlike for IGFBP-1, there is negligible variability during the day and, unlike IGFBP-1 and IGFBP-3, virtually no change during puberty. IGFBP-2 has also been identified in other body fluids such as cerebrospinal, amniotic and coelomic fluids, urine and seminal fluid.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Hu01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA053Hu61 Eukaryotic Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA053Hu61 Active Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Cell culture; Activity Assays.
Antibodies PAA053Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; FCM
MAA053Hu22 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Hu ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Mu01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA053Mu01 Active Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Cell culture; Activity Assays.
EPA053Mu61 Eukaryotic Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA053Mu02 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA053Mu61 Active Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Cell culture; Activity Assays.
RPA053Mu03 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA053Mu04 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA053Mu05 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA053Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
LAA053Mu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC.
PAA053Mu06 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Mu ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Ra01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA053Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
LAA053Ra71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC.
LAA053Ra81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
MAA053Ra21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Ra ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Po01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA053Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
MAA053Po21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Po ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Bo01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA053Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
MAA053Bo21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Bo ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA053Ga01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA053Ga21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAA053Ga01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
Assay Kits SEA053Ga ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."EMBO J. 8:2497-2502(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."J. Biol. Chem. 265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and localization of the human insulin-like growth factor-binding protein 2 gene."Biochem. Biophys. Res. Commun. 176:1250-1255(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)."Exp. Eye Res. 52:549-561(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the human insulin-like growth factor binding protein-2 gene."Mol. Endocrinol. 6:826-836(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."Growth Regul. 1:125-130(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)."J. Mol. Biol. 364:690-704(2006) [PubMed] [Europe PMC] [Abstract]