Myasthenia gravis(MG)is an autoimmune disease causing neuromuscular junction (NMJ) impairment, characterized by weakness and easy fatigability on exertion involving different skeletal muscle districts. The autoimmune attack is mediated by autoantibodies targeting key functional and structural NMJ proteins: the acetylcholine receptor (AChR), the muscle-specific kinase receptor (MuSK) or the lowdensity lipoprotein receptor-related protein 4 (LRP4).Recommendations for MG treatment have been published. However, treatment improvement of myasthenic patients is still a medical need as a substantial proportion of them are refractory or intolerant. Recently, several papers have reported studies......2023-05-23

On March 27, 2023,Lian-Wen Qi and Lei Zhang, State Key Laboratory of Natural Medicines, China Pharmaceutical University, China, and their team published a paper titled “Neuraminidase 1 promotes renal fibrosis development in male mice” in Nature Communications. This study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases.The antibody[FITC-Linked Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1),LAA785Mu81] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The functions of the influenza virus neuraminidase has been well documented but those of the mamma......2023-05-22

Anxiety disorders are among the most prevalent and disabling psychiatric disorders. The core feature of anxiety disorders is excessive fear and anxiety and related behavioral disturbances.Patients with anxiety disorders experience substantial physical and emotional discomfort and have elevated rates of substance use and medical illnesses.Furthermore, anxiety disorders are characterized by high comorbidity along with other mental disorders (eg, mood, substance-abuse, or personality disorders). Compounding this, response rates to first-line pharmacological and psychological treatments are less than 50%. Recently, several papers have reported anxiety related studies, which may provide hel......2023-05-15

On April 7, 2023, Lingqiang Zhang's team, State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, China, and Cui Hua Liu's team, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China, published a paper titled “OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2” in Signal Transduction and Targeted Therapy. Their results suggested that OTUB1 positively regulates osteogenic differentiation and mineralization in bone homeostasis by controlling FGFR2 stability.The kits [ELISA Kit for Cross Linked C-Telopeptide Of Type I Collagen (CTX......2023-05-15

2023-04-24

Cancer therapy using monoclonal antibodies (mAbs) is a rapidly developing field, due in large part to naturally favorable attributes such as specificity, potency, and metabolic stability. Most of them act by binding to transmembrane receptors or soluble ligands, thereby interfering with their signal transduction pathways, resulting in inhibition of tumor cell proliferation or angiogenesis. Due to the presence of an intact Fc domain, mAbs can evoke antibody-dependent cell-mediated cytotoxicity by attracting complement or effector cells of the human immune system to the cancer site. mAbs have also been used as targeting moieties for the delivery of nanomedicinesor conjugating to cytotoxi......2023-04-21