Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is critical in light of the increased incidence of dementia-related disorders forecasted in the growing older population. Systemic rejuvenating interventions—such as heterochronic parabiosis (in which the circulatory systems of young and aged animals are joined)—can reverse age-related impairments in neurogenesis, synaptic plasticity and cognitive function in aged mice. Reports using heterochronic parabiosis led to studies in which systemic administration of blood plasma preparations derived from young or exercised mice was demonstrated to rejuvenate the aged brain. Although the field of rejuv......2023-09-08

Parkinson's disease (PD) is the second most common progressive neurodegenerative disease and its incidence is expected to increase as the global population ages.Resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal Lewy Bodies, idiopathic PD is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals. Given that aggregated and misfolded a-synuclein (a-Syn)species are the major constituents of Lewy bodies, PD is classified as a synucleinopathy. Numerous therapies have been developed that provide meaningful symptomatic benefits for the c......2023-09-05

Osteoarthritis (OA), the most common form of arthritis, affects more than 7% of the global population. The prevalence of osteoarthritis is high in individuals of advanced age (>65 years).OA is a typical degenerative disease characterized by abnormal neurovascularization. The invasion of nerves and vessels in the osteochondral junction is one of its hallmarks and is the primary reason for aggravated pain. Anti-inflammatory drug therapy and surgery are the major treatment modalities for OA. However, until recently, long-term disease remission has not been achieved, and the uncertain pathophysiological mechanisms of OA limit treatment options. Many cytokines, including semaphorins, net......2023-09-01

Bone tissue is a hard connective tissue of the human body and is constantly reshaped throughout the life of an individual. Bone tissue exerts both supporting and protective effects and can protect fragile organs within the body.When bone defect areas are small, most bones can undergo self-healing without any treatment. However, when bone tissue suffers damage beyond its ability to repair itself, bone damage can occur. Severe bone defects can be caused by tumor resection, severe trauma, infection, congenital malformation, osteogenesis imperfecta, rheumatoid arthritis, and osteoporosis, thus requiring clinical intervention. However, despite the high incidence of bone injury, treatment se......2023-08-31

On July 10, 2023,Tianfeng Chen, Department of Oncology, The First Affiliated Hospital, Department of Chemistry, China, and his team published a paper titled “Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2- Keap1-Driven Activation of Selenoproteins” in ACS Nano. This study not only constructs facile large-scale synthesis of translational Se nanomedicine to break through the bottleneck problem of nanomaterials but also sheds light on its application in the intervention and treatment of allergies.The kit[ELISA Kit for Histamine (HA), CEA927Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Easy recurr......2023-08-24

Periodontitis is a chronic inflammatory disease with an incidence of over 40% worldwide and has become one of the most common, challenging, and rapidly expanding oral diseases in recent years. It has been considered the main cause of tooth loss and is also connected with several system diseases, such as atherosclerosis and diabetes. Currently, the main strategy for treating periodontitis is to prevent disease progression, including mechanical debridement, antibiotics, anti-inflammatory drugs, and surgical techniques. However, the reconstruction of the periodontal tissue structure is hard to realize since the local infection and inflammation are difficult to eliminate. Recently, a numbe......2023-08-22