Monoclonal Antibody to Cathepsin D (CTSD)

CPSD; CLN10; Lysosomal Aspartyl Protease; Ceroid-Lipofuscinosis,Neuronal 10

Product No.MAB280Hu21
Organism SpeciesHomo sapiens (Human) Same name, Different species.
- All
- Human
- Mouse
- Rat
- Cavia
- Rabbit
- Simian
- Canine
- Porcine
- Bovine
- Caprine
- Multi-species
- Pan-species
- Others
SourceMonoclonal antibody preparation
HostMouse
Potency (Clone Number)C11
Ig Isotype IgG2b Kappa
PurificationProtein A + Protein G affinity chromatography
LabelNone
Immunogen EPB280Hu61-Eukaryotic Cathepsin D (CTSD)
Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
TraitsLiquid
Concentration1mg/mL
Organism Species Moren/a
ApplicationsWB; IHC; ICC; IP.
If the antibody is used in flow cytometry, please check FCM antibodies.
DownloadInstruction Manual
UOM 20µl100µl 200µl 1ml 10ml
FOB US$ 108 252 US$ 252 US$ 360 US$ 900 US$ 3600
For more details, please contact local distributors!

SPECIFITY

The antibody is a mouse monoclonal antibody raised against CTSD. It has been selected for its ability to recognize CTSD in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL
Immunohistochemistry: 5-20µg/mL
Immunocytochemistry: 5-20µg/mL
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine	Citations
Molecular Immunology	Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro ScienceDirect: S0161589011008297
21	Plasma Cathepsin D Levels: A Novel Tool to Predict Pediatric Hepatic Inflammation PubMed: 25732418
Scientific Reportes	Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention pubmed:27922112
Biomedicine & pharmacotherapy	Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms pubmed:28061403
JGH OPEN	Limited applicability of cathepsin D for the diagnosis and monitoring of non‐alcoholic steatohepatitis
Diabetologia	Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans Pubmed: 31690989
Antioxidants	Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity Pubmed: 32235809
Peptides	LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders 33253777
Cells	Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease 33445607
J Chem Neuroanat	Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers 33965515
Front Cell Infect Microbiol	PGRS Domain of Rv0297 of Mycobacterium tuberculosis Is Involved in Modulation of Macrophage Functions to Favor Bacterial Persistence 33042856
Nutr Metab Cardiovasc Dis	Serum CathepsinD in pregnancy: relation with metabolic and inflammatory markers and effects of fish oils and probiotics Pubmed:35304048
Biosensors	A Comparison of Various Chips Used for the Manufacture of Biosensors Applied in Non-Fluidic Array SPRi, Based on the Example of Determination of Cathepsin D Pubmed:35049649

Catalog No.	Related products for research use of Homo sapiens (Human) Organism species	Applications (RESEARCH USE ONLY!)
APB280Hu61	Active Cathepsin D (CTSD)	Cell culture; Activity Assays.
EPB280Hu61	Eukaryotic Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu01	Recombinant Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
APB280Hu62	Active Cathepsin D (CTSD)	Cell culture; Activity Assays.
EPB280Hu62	Eukaryotic Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu02	Recombinant Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu03	Recombinant Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu04	Recombinant Cathepsin D (CTSD)	Positive Control; Immunogen; SDS-PAGE; WB.
PAB280Hu02	Polyclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC; IP.
PAB280Hu01	Polyclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC; IP.
LAB280Hu71	Biotin-Linked Polyclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC.
MAB280Hu21	Monoclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC; IP.
MAB280Hu26	Monoclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC; IP.
MAB280Hu22	Monoclonal Antibody to Cathepsin D (CTSD)	WB; IHC; ICC; IP.
FAB280Hu02	Anti-Cathepsin D (CTSD) Monoclonal Antibody	Flow cytometry.
SEB280Hu	ELISA Kit for Cathepsin D (CTSD)	Enzyme-linked immunosorbent assay for Antigen Detection.
HEB280Hu	High Sensitive ELISA Kit for Cathepsin D (CTSD)	Enzyme-linked immunosorbent assay for Antigen Detection.
LMB280Hu	Multiplex Assay Kit for Cathepsin D (CTSD) ,etc. by FLIA (Flow Luminescence Immunoassay)	FLIA Kit for Antigen Detection.