SPARC Like Protein 1 (SPARCL1)

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SC1; PIG33; Mast9; Hevin; High endothelial venule protein

SPARC Like Protein 1 (SPARCL1)
Hevin is an evolutionarily conserved, 664-amino acid secreted protein. Hevin contains 7 potential N-linked glycosylation sites, an N-terminal signal peptide, a long acidic region rich in glu and asp, a cysteine-rich domain, and a C-terminal region with a 12-residue segment homologous to the calcium-binding loops of EF-hand structures in the calmodulin family of proteins . The 232 C-terminal amino acids of Hevin are 62% identical to the homologous portion of SPARC. Northern blot analysis revealed high expression of a 2.7-kb Hevin transcript in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes. Unlike SPARC, Hevin is absent from flat umbilical vein endothelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM267Hu01 Recombinant SPARC Like Protein 1 (SPARCL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM267Hu01 Polyclonal Antibody to SPARC Like Protein 1 (SPARCL1) WB; IHC
MAM267Hu21 Monoclonal Antibody to SPARC Like Protein 1 (SPARCL1) WB; IHC; ICC; IP.
Assay Kits SEM267Hu ELISA Kit for SPARC Like Protein 1 (SPARCL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SPARC Like Protein 1 (SPARCL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SPARC Like Protein 1 (SPARCL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SPARC Like Protein 1 (SPARCL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SPARC Like Protein 1 (SPARCL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SPARC Like Protein 1 (SPARCL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM267Ra01 Recombinant SPARC Like Protein 1 (SPARCL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPM267Ra02 Recombinant SPARC Like Protein 1 (SPARCL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPM267Ra03 Recombinant SPARC Like Protein 1 (SPARCL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM267Ra01 Polyclonal Antibody to SPARC Like Protein 1 (SPARCL1) WB; IHC; ICC; IP.
MAM267Ra21 Monoclonal Antibody to SPARC Like Protein 1 (SPARCL1) WB; IHC; ICC; IP.
PAM267Ra02 Polyclonal Antibody to SPARC Like Protein 1 (SPARCL1) WB; IHC; ICC; IP.
Assay Kits SEM267Ra ELISA Kit for SPARC Like Protein 1 (SPARCL1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC."Immunity 2:113-123(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  6. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]