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Granzyme H (GZMH)

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CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2; Cathepsin G-Like 2,Protein h-CCPX; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C

Granzyme H (GZMH)
CCC L575
HGNC 4710
MGI 109253
PubMed 23269243
RGD 628603
UniProt P20718
Wiki GZMH
GZMHis located in a cluster on 14q11.2 with cathepsin G and CTSGL1. A similar cluster of genes in the mouse is located on chromosome 14 near the TCRA locus.
Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.Cytotoxic T cells and natural killer cells release a protein called perforin, which attacks the target cells. Researchers used to think that perforin creates pores within the cells, through which the granzymes can enter, inducing apoptosis. However, new evidence indicates that GrB complex can enter a cell through the mannose 6-phosphate receptor and is enclosed in a vesicle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL575Hu01 Recombinant Granzyme H (GZMH) Positive Control; Immunogen; SDS-PAGE; WB.
APL575Hu01 Active Granzyme H (GZMH) Cell culture; Activity Assays.
Antibodies PAL575Hu01 Polyclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
MAL575Hu21 Monoclonal Antibody to Granzyme H (GZMH) WB; IHC; ICC; IP.
Assay Kits SEL575Hu ELISA Kit for Granzyme H (GZMH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Granzyme H (GZMH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Granzyme H (GZMH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Granzyme H (GZMH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Granzyme H (GZMH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme H (GZMH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Granzyme H (GZMH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Granzyme H (GZMH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Granzyme H (GZMH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Granzyme H (GZMH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme H (GZMH) ELISA Kit Customized Service Offer
  1. "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family."Biochemistry 29:4042-4049(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and evolutionary origin of the human granzyme H gene."Int. Immunol. 3:57-66(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)."Tissue Antigens 35:220-228(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif."J. Immunol. 188:765-773(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of SERPINB1 as a physiological inhibitor of human granzyme H."J. Immunol. 190:1319-1330(2013) [PubMed] [Europe PMC] [Abstract]