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HLA-B Associated Transcript 3 (BAT3)

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BAG6; Protein G3; Protein Scythe; BCL2-associated athanogene 6; BAG family molecular chaperone regulator 6; Large proline-rich protein BAG6

HLA-B Associated Transcript 3 (BAT3)
CCC J947
HGNC 13919
MGI 1919439
PubMed 2156268
RGD 71064
UniProt P46379
Wiki BAT3
BAT3 contains an N-terminal ubiquitin-like domain, and both BAT2 and BAT3 are rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids.The presence of additional genes was suggested by a large cluster of CpG islands. With cosmid probes, 5 distinct transcripts, including BAT3, were detected in RNA samples from a variety of cell lines, and the corresponding cDNA clones were isolated.BAT3 formed a complex with p300 (EP300), and an increased amount of BAT3 enhanced recruitment of p53 to p300 and facilitated subsequent p53 acetylation. In contrast, Bat3-depleted cells showed reduced p53-p300 complex formation and decreased p53 acetylation. Thymocytes from Bat3-deficient mice exhibited reduced p53-mediated induction of Puma and p21 and were resistant to DNA damage-induced apoptosis in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPJ947Hu61 Eukaryotic HLA-B Associated Transcript 3 (BAT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to HLA-B Associated Transcript 3 (BAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA-B Associated Transcript 3 (BAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA-B Associated Transcript 3 (BAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA-B Associated Transcript 3 (BAT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ947Mu01 Recombinant HLA-B Associated Transcript 3 (BAT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ947Mu02 Recombinant HLA-B Associated Transcript 3 (BAT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ947Mu01 Polyclonal Antibody to HLA-B Associated Transcript 3 (BAT3) WB; IHC; ICC; IP.
PAJ947Mu02 Polyclonal Antibody to HLA-B Associated Transcript 3 (BAT3) WB; IHC; ICC; IP.
Assay Kits SEJ947Mu ELISA Kit for HLA-B Associated Transcript 3 (BAT3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA-B Associated Transcript 3 (BAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA-B Associated Transcript 3 (BAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA-B Associated Transcript 3 (BAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA-B Associated Transcript 3 (BAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA-B Associated Transcript 3 (BAT3) ELISA Kit Customized Service Offer
  1. "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain."Proc. Natl. Acad. Sci. U.S.A. 87:2374-2378(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3."J. Biol. Chem. 279:19264-19275(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53."Genes Dev. 21:848-861(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells."Immunity 27:965-974(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  14. "BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression."Mol. Cell. Biol. 28:6720-6729(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function."PLoS ONE 3:E3377-E3377(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates."Infect. Immun. 78:3905-3919(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Bat3 promotes the membrane integration of tail-anchored proteins."J. Cell Sci. 123:2170-2178(2010) [PubMed] [Europe PMC] [Abstract]
  21. "A ribosome-associating factor chaperones tail-anchored membrane proteins."Nature 466:1120-1124(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6."Mol. Cell 55:227-237(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Solution structure of the N-terminal ubiquitin-like domain in the human BAT3 protein."Submitted (JUL-2005) to the PDB data bank