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Peptidyl Arginine Deiminase Type IV (PADI4)

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PAD; PADI5; PDI4; PDI5; Peptidyl Arginine Deiminase Type V; Peptidylarginine deiminase IV

Peptidyl Arginine Deiminase Type IV (PADI4)
CCC F709
HGNC 18368
MGI 1338898
PubMed 21655091
RGD 3290
UniProt Q9UM07
Wiki PADI4
PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
The deduced 663-amino acid protein, approximately 50% identical to rat PAD types I, II, and III and 73% identical with rat keratinocyte PAD IV, is most conserved in the C terminal two-thirds of the sequence. Functional analysis indicated that the recombinant protein is fully active against arginine-containing substrates. Western blot analysis showed that expression of a 67-kD protein is induced by incubation of HL60 cells with differentiation factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF709Hu01 Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Positive Control; Immunogen; SDS-PAGE; WB.
APF709Hu01 Active Peptidyl Arginine Deiminase Type IV (PADI4) Cell culture; Activity Assays.
Antibodies PAF709Hu01 Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) IHC
MAF709Hu21 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB
MAF709Hu22 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB
MAF709Hu23 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB
MAF709Hu24 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB
Assay Kits SEF709Hu ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) ELISA Kit Customized Service Offer
  1. "Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)."J. Biol. Chem. 274:27786-27792(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils."J. Leukoc. Biol. 70:46-51(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis." Nat. Genet. 34:395-402(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Histone deimination antagonizes arginine methylation."Cell 118:545-553(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human PAD4 regulates histone arginine methylation levels via demethylimination."Science 306:279-283(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Comparison of enzymatic properties between hPADI2 and hPADI4."Biochem. Biophys. Res. Commun. 327:192-200(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination."Proc. Natl. Acad. Sci. U.S.A. 102:3611-3616(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Histone deimination as a response to inflammatory stimuli in neutrophils."J. Immunol. 180:1895-1902(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation."Arthritis Rheum. 62:1630-1640(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for Ca(2+)-induced activation of human PAD4."Nat. Struct. Mol. Biol. 11:777-783(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4."Proc. Natl. Acad. Sci. U.S.A. 103:5291-5296(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization."Biochemistry 45:11727-11736(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene."Acta Crystallogr. D 67:112-118(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The development of N-alpha-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors."J. Med. Chem. 54:6919-6935(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors."ACS Chem. Biol. 7:160-165(2012) [PubMed] [Europe PMC] [Abstract]
  20. "High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach."J. Mol. Med. 82:762-767(2004) [PubMed] [Europe PMC] [Abstract]