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Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G)

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NBR13; Cav3.1; Voltage-gated calcium channel subunit alpha Cav3.1

Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G)
CCC F242
HGNC 1394
MGI 1201678
PubMed 10493502
RGD 68942
UniProt O43497
Wiki CACNA1G
Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.
The authors used the partial cDNA to isolate additional human, rat, and mouse alpha-1G cDNAs. Northern blot analysis of human and rat tissues indicated that the alpha-1G gene was expressed as an 8.5-kb mRNA predominantly in brain. An additional 9.7-kb transcript was also detected. When expressed in Xenopus oocytes, the rat alpha-1G channel exhibited the properties of a low-voltage-activated T-type calcium channel.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit (CACNa1G) ELISA Kit Customized Service Offer
  1. "Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors."Cancer Res. 59:4535-4541(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit."Neurosci. Lett. 274:143-146(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain."FEBS Lett. 466:54-58(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels."J. Biol. Chem. 275:6090-6100(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations."Proteins 64:320-342(2006) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel."Nature 391:896-900(1998) [PubMed] [Europe PMC] [Abstract]