Editing Calcium Channel, Voltage Dependent, T-Type, Alpha 1G Subunit(CACNa1G)

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Summary	Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. The authors used the partial cDNA to isolate additional human, rat, and mouse alpha-1G cDNAs. Northern blot analysis of human and rat tissues indicated that the alpha-1G gene was expressed as an 8.5-kb mRNA predominantly in brain. An additional 9.7-kb transcript was also detected. When expressed in Xenopus oocytes, the rat alpha-1G channel exhibited the properties of a low-voltage-activated T-type calcium channel.
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