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Sirtuin 7 (SIRT7)

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SIR2L7; NAD-Dependent Deacetylase Sirtuin-7; Silent Mating Type Information Regulation 2 Homolog 7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7

Sirtuin 7 (SIRT7)
CCC E917
HGNC 14935
MGI 2385849
PubMed 22722849
UniProt Q9NRC8
Wiki SIRT7

NAD-dependent deacetylase sirtuin-7 is  a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Sir2 is short for Silent mating type Information Regulation-2 and sirtuin stands for Sir2-homolog. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.

Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE917Hu01 Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE917Hu01 Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
MAE917Hu21 Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
Assay Kits SEE917Hu ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sirtuin 7 (SIRT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sirtuin 7 (SIRT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sirtuin 7 (SIRT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sirtuin 7 (SIRT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sirtuin 7 (SIRT7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE917Ra01 Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
RPE917Ra02 Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE917Ra01 Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
PAE917Ra02 Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
LAE917Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC.
Assay Kits SEE917Ra ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins."Biochem. Biophys. Res. Commun. 273:793-798(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues."Br. J. Cancer 86:917-923(2002) [PubMed] [Europe PMC] [Abstract]
  7. ErratumBr. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]
  8. "'SIRT8' expressed in thyroid cancer is actually SIRT7."Br. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription."Genes Dev. 20:1075-1080(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis."J. Cell Sci. 122:489-498(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription."Mol. Cell. Proteomics 11:M111.015156.01-M111.015156.17(2012) [PubMed] [Europe PMC] [Abstract]
  13. "SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation."Nature 487:114-118(2012) [PubMed] [Europe PMC] [Abstract]