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Sphingosine 1 Phosphate Lyase 1 (SGPL1)

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SPL; S1PL; Sphingosine-1-phosphate aldolase

Sphingosine 1 Phosphate Lyase 1 (SGPL1)
CCC E691
HGNC 10817
MGI 1261415
PubMed 23700419
RGD 628599
UniProt O95470
Wiki SGPL1
Sphingosine-1-phosphate (SPP) participates in the proliferative signal transduction pathways of mammalian cells. SPP synthesis is catalyzed by sphingosine kinase, and SPP degradation is catalyzed by SPP lyase (SPL). The first SPL gene cloned, BST1 ('bestowed of sphingosine tolerance'), was isolated from budding yeast . A yeast mutant strain containing a deletion of the entire BST1 coding region is sensitive to the growth-inhibitory effects of D-erythro-sphingosine, due to its inability to degrade SPP. Spl, that has 59% sequence similarity to the BST1 gene product. They showed that this cDNA can functionally complement the yeast BST1 deletion, restoring a sphingosine-resistant phenotype. Northern blot analysis detected Spl expression in several mouse tissues, with the highest level found in the liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE691Hu01 Recombinant Sphingosine 1 Phosphate Lyase 1 (SGPL1) Positive Control; Immunogen; SDS-PAGE; WB.
APE691Hu01 Active Sphingosine 1 Phosphate Lyase 1 (SGPL1) Cell culture; Activity Assays.
Antibodies PAE691Hu01 Polyclonal Antibody to Sphingosine 1 Phosphate Lyase 1 (SGPL1) WB; IHC
Assay Kits n/a CLIA Kit for Sphingosine 1 Phosphate Lyase 1 (SGPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine 1 Phosphate Lyase 1 (SGPL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE691Mu01 Recombinant Sphingosine 1 Phosphate Lyase 1 (SGPL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPE691Mu02 Recombinant Sphingosine 1 Phosphate Lyase 1 (SGPL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE691Mu01 Polyclonal Antibody to Sphingosine 1 Phosphate Lyase 1 (SGPL1) WB; IHC; ICC; IP.
PAE691Mu02 Polyclonal Antibody to Sphingosine 1 Phosphate Lyase 1 (SGPL1) WB; IHC; ICC; IP.
Assay Kits SEE691Mu ELISA Kit for Sphingosine 1 Phosphate Lyase 1 (SGPL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sphingosine 1 Phosphate Lyase 1 (SGPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sphingosine 1 Phosphate Lyase 1 (SGPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sphingosine 1 Phosphate Lyase 1 (SGPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sphingosine 1 Phosphate Lyase 1 (SGPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine 1 Phosphate Lyase 1 (SGPL1) ELISA Kit Customized Service Offer
  1. "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22."Biochim. Biophys. Acta 1487:128-134(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis."J. Biol. Chem. 279:1281-1290(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis."J. Med. Chem. 57:5074-5084(2014) [PubMed] [Europe PMC] [Abstract]