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Phosphofructokinase, Muscle (PFKM)

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PFK1; PFKX; Phosphofructokinase 1; Phosphofructo-1-kinase isozyme A; 6-Phosphofructokinase Polypeptide X; Fructose-6-Phosphate 1-Phosphotransferase

Phosphofructokinase, Muscle (PFKM)
CCC D405
HGNC 8877
MGI 97548
PubMed 6213050
RGD 68419
UniProt P08237
Wiki PFKM
Phosphofructokinase-1 (PFK-1) is the most important regulatory enzyme (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. PFK-1 catalyzes one of the important "committed" steps of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.
PFK1 is allosterically inhibited by ATP and citrate (from the citric acid cycle) and its product. It is also inhibited by low pH to prevent the accumulation of hydrogen ions in muscle. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.PFK1 is allosterically activated by a high concentration of AMP, but the most potent activator is fructose 2,6-bisphosphate, which is also produced from fructose-6-phosphate by PFK2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD405Hu01 Recombinant Phosphofructokinase, Muscle (PFKM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD405Hu01 Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB; IHC; ICC; IP.
MAD405Hu21 Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB; IHC; ICC; IP.
Assay Kits SED405Hu ELISA Kit for Phosphofructokinase, Muscle (PFKM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofructokinase, Muscle (PFKM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofructokinase, Muscle (PFKM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofructokinase, Muscle (PFKM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD405Ra01 Recombinant Phosphofructokinase, Muscle (PFKM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD405Ra01 Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB; IHC; ICC; IP.
MAD405Ra21 Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB; IHC; ICC; IP.
Assay Kits SED405Ra ELISA Kit for Phosphofructokinase, Muscle (PFKM) Enzyme-linked immunosorbent assay for Antigen Detection.
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