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Asporin (ASPN)

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PLAP1; SLRR1C; Periodontal ligament-associated protein 1

Asporin (ASPN)
CCC C321
HGNC 14872
MGI 1913945
PubMed 18336287
RGD 1549776
UniProt Q9BXN1
Wiki Asporin

Asporin, ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin.Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung.
Variation in the poly-Asp region of ASPN is associated with osteoarthritis susceptibility type 3 (OS3) ; also known as osteoarthritis of knee/hip. Osteoarthritis is a common disease that produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint cartilage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC321Hu01 Recombinant Asporin (ASPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC321Hu01 Polyclonal Antibody to Asporin (ASPN) WB; IHC; ICC; IP.
MAC321Hu22 Monoclonal Antibody to Asporin (ASPN) WB; IHC; ICC; IP.
Assay Kits SEC321Hu ELISA Kit for Asporin (ASPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC321Mu01 Recombinant Asporin (ASPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC321Mu02 Recombinant Asporin (ASPN) Positive Control; Immunogen; SDS-PAGE; WB.
APC321Mu01 Active Asporin (ASPN) Cell culture; Activity Assays.
RPC321Mu03 Recombinant Asporin (ASPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC321Mu04 Recombinant Asporin (ASPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC321Mu01 Polyclonal Antibody to Asporin (ASPN) WB; IHC; ICC; IP.
PAC321Mu02 Polyclonal Antibody to Asporin (ASPN) WB; IHC; ICC; IP.
Assay Kits SEC321Mu ELISA Kit for Asporin (ASPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asporin (ASPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asporin (ASPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asporin (ASPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asporin (ASPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asporin (ASPN) ELISA Kit Customized Service Offer
  1. "Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan."J. Biol. Chem. 276:12201-12211(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene."Gene 275:279-286(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family."J. Biol. Chem. 276:12212-12221(2001) [PubMed] [Europe PMC] [Abstract]
  7. "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis."Nat. Genet. 37:138-144(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Mechanisms for asporin function and regulation in articular cartilage."J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Association of the asporin D14 allele with lumbar-disc degeneration in Asians."Am. J. Hum. Genet. 82:744-747(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization."Biochem. J. 423:53-59(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]