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Collagen Type IV Alpha 3 (COL4a3)

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COL4-A3; Tumstatin; Goodpasture Antigen; Collagen Alpha-3(IV)chain

Collagen Type IV Alpha 3 (COL4a3)
CCC C143
HGNC 2204
MGI 104688
PubMed 11044206
RGD 71085
UniProt Q01955
Wiki COL4A3

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen.

Collagen alpha-3(IV) chain. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC143Hu01 Recombinant Collagen Type IV Alpha 3 (COL4a3) Positive Control; Immunogen; SDS-PAGE; WB.
RPC143Hu02 Recombinant Collagen Type IV Alpha 3 (COL4a3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC143Hu01 Polyclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) WB; IHC; ICC; IP.
MAC143Hu22 Monoclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) WB; IHC; ICC; IP.
MAC143Hu21 Monoclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) WB; IHC; ICC; IP.
MAC143Hu23 Monoclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) WB; IHC; ICC; IP.
Assay Kits SEC143Hu ELISA Kit for Collagen Type IV Alpha 3 (COL4a3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 3 (COL4a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 3 (COL4a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 3 (COL4a3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 3 (COL4a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 3 (COL4a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 3 (COL4a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 3 (COL4a3) ELISA Kit Customized Service Offer
  1. "Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues."J. Biol. Chem. 269:23013-23017(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome."J. Am. Soc. Nephrol. 12:97-106(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36."FEBS Lett. 424:11-16(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen."J. Clin. Invest. 89:592-601(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Exon/intron structure of the human alpha 3(IV) gene encompassing the Goodpasture antigen (alpha 3(IV)NC1). Identification of a potentially antigenic region at the triple helix/NC1 domain junction."J. Biol. Chem. 267:19780-19784(1992) [PubMed] [Europe PMC] [Abstract]
  7. ErratumJ. Biol. Chem. 269:17358-17358(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms."Eur. J. Biochem. 229:754-760(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Distinct antitumor properties of a type IV collagen domain derived from basement membrane."J. Biol. Chem. 275:21340-21348(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Alternative splicing of the NC1 domain of the human alpha 3(IV) collagen gene. Differential expression of mRNA transcripts that predict three protein variants with distinct carboxyl regions."J. Biol. Chem. 269:2342-2348(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen."Am. J. Hum. Genet. 49:545-554(1991) [PubMed] [Europe PMC] [Abstract]
  12. "The human mRNA encoding the Goodpasture antigen is alternatively spliced."J. Biol. Chem. 268:12090-12094(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains."J. Biol. Chem. 269:26172-26177(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen."J. Biol. Chem. 274:12642-12649(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties."J. Biol. Chem. 275:23745-23750(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Autosomal dominant Alport syndrome caused by a COL4A3 splice site mutation."Kidney Int. 58:1870-1875(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains."J. Biol. Chem. 277:40075-40083(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins."Proc. Natl. Acad. Sci. U.S.A. 100:4766-4771(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Implication of tumstatin in tumor progression of human bronchopulmonary carcinomas."Hum. Pathol. 35:1218-1222(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Mutations in the type IV collagen alpha 3 (COL4A3) gene in autosomal recessive Alport syndrome."Hum. Mol. Genet. 3:1269-1273(1994) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria."J. Am. Soc. Nephrol. 13:1248-1254(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome."Hum. Mutat. 26:60-60(2005) [PubMed] [Europe PMC] [Abstract]