≡

Collagen Type XV (COL15)

[Edit]

COL15A1; COL15-A1; Collagen Alpha-1(XV)chain; Restin; Endostatin-XV; Related to endostatin;

Collagen Type XV (COL15)
CCC C137
HGNC 2192
MGI 88449
PubMed 11068203
RGD 1310820
UniProt P39059
Wiki COL15A1

Collagen alpha-1(XV) chain is the alpha chain of type XV collagen, a member of the FACIT collagen family . Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma.

Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.The highest degree of homology between collagens type XV and type XVIII involves the C-terminal endostatin sequence. The corresponding fragment in type XV collagen has also been shown to have antiangiogenic activity .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC137Hu01 Recombinant Collagen Type XV (COL15) Positive Control; Immunogen; SDS-PAGE; WB.
APC137Hu01 Active Collagen Type XV (COL15) Cell culture; Activity Assays.
Antibodies PAC137Hu01 Polyclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IP.
MAC137Hu22 Monoclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IP.
LAC137Hu71 Biotin-Linked Polyclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC.
LAC137Hu81 FITC-Linked Polyclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IF.
LAC137Hu72 Biotin-Linked Monoclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC.
LAC137Hu82 FITC-Linked Monoclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IF.
Assay Kits SEC137Hu ELISA Kit for Collagen Type XV (COL15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC137Mu01 Recombinant Collagen Type XV (COL15) Positive Control; Immunogen; SDS-PAGE; WB.
RPC137Mu02 Recombinant Collagen Type XV (COL15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC137Mu01 Polyclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IP.
PAC137Mu02 Polyclonal Antibody to Collagen Type XV (COL15) WB; IHC; ICC; IP.
Assay Kits SEC137Mu ELISA Kit for Collagen Type XV (COL15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type XV (COL15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type XV (COL15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type XV (COL15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type XV (COL15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XV (COL15) ELISA Kit Customized Service Offer
  1. "Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene."J. Biol. Chem. 269:4773-4779(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene."J. Biol. Chem. 273:17824-17831(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen."J. Biol. Chem. 269:4042-4046(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region."Proc. Natl. Acad. Sci. U.S.A. 89:10144-10148(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22."Genomics 14:220-224(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of novel endogenous proteolytic forms of the human angiogenesis inhibitors restin and endostatin."Biochim. Biophys. Acta 1747:161-170(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin."Biochem. Biophys. Res. Commun. 255:735-739(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells."J. Biol. Chem. 275:22339-22347(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]