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Noggin inhibits TGF-beta signal transduction by binding to TGF-beta family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming TGF-beta superfamily signaling proteins, such as BMP4. By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Hu01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC130Hu02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC130Hu01 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
| EPC130Hu61 | Eukaryotic Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC130Hu01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| MAC130Hu22 | Monoclonal Antibody to Noggin (NOG) | WB,IHC | |
| PAC130Hu02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
| LAC130Hu71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
| LAC130Hu81 | FITC-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IF. | |
| MAC130Hu24 | Monoclonal Antibody to Noggin (NOG) | WB,IHC | |
| MAC130Hu26 | Monoclonal Antibody to Noggin (NOG) | WB,IHC | |
| LAC130Hu76 | Biotin-Linked Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
| MAC130Hu21 | Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEC130Hu | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Mu01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC130Mu02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC130Mu01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| PAC130Mu02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEC130Mu | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Ra01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC130Ra02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC130Ra01 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
| APC130Ra02 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
| Antibodies | PAC130Ra01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| PAC130Ra02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEC130Ra | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Ca01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC130Ca01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| LAC130Ca71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Po01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC130Po01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| LAC130Po71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC130Ga01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC130Ga01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
| LAC130Ga71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
- "A GDF5 point mutation strikes twice--causing BDA1 and SYNS2."PLoS Genet. 9:E1003846-E1003846(2013) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."Nature 420:636-642(2002) [PubMed] [Europe PMC] [Abstract]
- "Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis."Nat. Genet. 21:302-304(1999) [PubMed] [Europe PMC] [Abstract]
- "Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."Clin. Genet. 60:447-451(2001) [PubMed] [Europe PMC] [Abstract]
- "Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."Genet. Med. 3:349-353(2001) [PubMed] [Europe PMC] [Abstract]
- "Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin."Am. J. Hum. Genet. 71:618-624(2002) [PubMed] [Europe PMC] [Abstract]
- "Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."Hum. Mutat. 19:308-308(2002) [PubMed] [Europe PMC] [Abstract]
- "The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene."Clin. Dysmorphol. 14:73-80(2005) [PubMed] [Europe PMC] [Abstract]
- "A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN."Am. J. Hum. Genet. 81:388-396(2007) [PubMed] [Europe PMC] [Abstract]
- "Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."Am. J. Med. Genet. A 152:1540-1544(2010) [PubMed] [Europe PMC] [Abstract]