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Complement Factor B (CFB)

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CF-B; BF; BFD; CFAB; GBG; H2-Bf; PBF2; B-Factor; Properdin; Properdin factor B; C3/C5 convertase; Glycine-rich beta glycoprotein

Complement Factor B (CFB)
CCC C011
HGNC 1037
MGI 105975
PubMed 19277984
RGD 2204
UniProt P00751
Wiki CFB

Complement factor B is a a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC011Hu01 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Hu02 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Hu03 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Hu04 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
APC011Hu03 Active Complement Factor B (CFB) Cell culture; Activity Assays.
RPC011Hu05 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
EPC011Hu61 Eukaryotic Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC011Hu01 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC
MAC011Hu22 Monoclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
PAC011Hu02 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
PAC011Hu03 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC
LAC011Hu71 Biotin-Linked Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC.
PAC011Hu04 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
Assay Kits SEC011Hu ELISA Kit for Complement Factor B (CFB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC011Mu01 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Mu02 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Mu03 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
APC011Mu01 Active Complement Factor B (CFB) Cell culture; Activity Assays.
APC011Mu03 Active Complement Factor B (CFB) Cell culture; Activity Assays.
Antibodies PAC011Mu01 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
PAC011Mu02 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
LAC011Mu71 Biotin-Linked Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC.
LAC011Mu72 Biotin-Linked Monoclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC.
Assay Kits SEC011Mu ELISA Kit for Complement Factor B (CFB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC011Ra01 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Ra02 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Ra03 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC011Ra04 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC011Ra01 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
PAC011Ra02 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
PAC011Ra03 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
LAC011Ra71 Biotin-Linked Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC.
PAC011Ra04 Polyclonal Antibody to Complement Factor B (CFB) WB; IHC; ICC; IP.
Assay Kits SEC011Ra ELISA Kit for Complement Factor B (CFB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC011Si01 Recombinant Complement Factor B (CFB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Complement Factor B (CFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Factor B (CFB) Polyclonal Antibody Customized Service Offer
Assay Kits SEC011Si ELISA Kit for Complement Factor B (CFB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular characterization of human complement factor B subtypes."Immunogenetics 32:309-312(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human factor B. Complete cDNA sequence of the BF*S allele."Hum. Immunol. 39:49-53(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase."Immunobiology 188:221-232(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression."Mol. Immunol. 30:1587-1592(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Complete primary structure for the zymogen of human complement factor B."J. Biol. Chem. 259:3407-3412(1984) [PubMed] [Europe PMC] [Abstract]
  9. "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment."Biochem. J. 209:61-70(1983) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular cloning and characterization of the gene coding for human complement protein factor B."Proc. Natl. Acad. Sci. U.S.A. 80:4464-4468(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product."Proc. Natl. Acad. Sci. U.S.A. 79:5661-5665(1982) [PubMed] [Europe PMC] [Abstract]
  12. "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen."EMBO J. 3:153-157(1984) [PubMed] [Europe PMC] [Abstract]
  13. "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."Cell 48:331-342(1987) [PubMed] [Europe PMC] [Abstract]
  14. "The principal site of glycation of human complement factor B."Biochem. J. 274:473-480(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Deficiency in complement factor B."N. Engl. J. Med. 369:1667-1669(2013) [PubMed] [Europe PMC] [Abstract]
  18. "New structural motifs on the chymotrypsin fold and their potential roles in complement factor B."EMBO J. 19:164-173(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Factor B structure provides insights into activation of the central protease of the complement system."Nat. Struct. Mol. Biol. 14:224-228(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex."EMBO J. 28:2469-2478(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."Nat. Genet. 38:458-462(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome."Proc. Natl. Acad. Sci. U.S.A. 104:240-245(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]