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Protein S (PROS)

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PSA; PS; PS26; PS21; PS22; PS23; PS24; PS25; VKDPS; VKDP-S; Protein Sa; Vitamin K Dependent Protein S

Protein S (PROS)
CCC B971
HGNC 9456
MGI 1095733
PubMed 7545463
RGD 620971
UniProt P07225
Wiki PROS1

Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. The best characterized function of Protein S is its role in the anti coagulation pathway, it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. Only the free form has cofactor activity.

Protein S can bind to negatively charged phospholipids via the carboxylated GLA domain. This property allows Protein S to function in the removal of cells which are undergoing apoptosis. Apoptosis is a form of cell death that is used by the body to remove unwanted or damaged cells from tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB971Hu01 Recombinant Protein S (PROS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB971Hu02 Recombinant Protein S (PROS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB971Hu01 Polyclonal Antibody to Protein S (PROS) WB; IHC; ICC; IP.
MAB971Hu22 Monoclonal Antibody to Protein S (PROS) WB; IHC; ICC; IP.
PAB971Hu02 Polyclonal Antibody to Protein S (PROS) WB; IHC; ICC; IP.
LAB971Hu71 Biotin-Linked Polyclonal Antibody to Protein S (PROS) WB; IHC; ICC.
LAB971Hu72 Biotin-Linked Monoclonal Antibody to Protein S (PROS) WB; IHC; ICC.
Assay Kits SEB971Hu ELISA Kit for Protein S (PROS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein S (PROS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein S (PROS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein S (PROS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein S (PROS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein S (PROS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB971Ra01 Recombinant Protein S (PROS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB971Ra02 Recombinant Protein S (PROS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB971Ra01 Polyclonal Antibody to Protein S (PROS) WB; IHC; ICC; IP.
PAB971Ra02 Polyclonal Antibody to Protein S (PROS) WB; IHC; ICC; IP.
Assay Kits SEB971Ra ELISA Kit for Protein S (PROS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein S (PROS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein S (PROS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein S (PROS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein S (PROS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein S (PROS) ELISA Kit Customized Service Offer
  1. "Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing."FEBS Lett. 222:186-190(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of human liver cDNA encoding a protein S precursor."Proc. Natl. Acad. Sci. U.S.A. 84:349-353(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the human protein S genes."Biochemistry 29:7845-7852(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution."Biochemistry 29:7853-7861(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation."Proc. Natl. Acad. Sci. U.S.A. 83:6716-6720(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of eight point mutations in protein S deficiency type I -- analysis of 15 pedigrees."Thromb. Haemost. 73:750-755(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the Ca2+-binding EGF3-4 pair from vitamin K-dependent protein S: identification of an unusual fold in EGF3."Biochemistry 44:8782-8789(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460."Blood 76:538-548(1990) [PubMed] [Europe PMC] [Abstract]
  13. Unpublished observations (SEP-1993)
  14. "Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S."Blood 83:683-690(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene."Blood 85:130-138(1995) [PubMed] [Europe PMC] [Abstract]
  16. "Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy."Blood 86:2632-2641(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Protein S deficiency type I: identification of point mutations in 9 of 10 families."Blood 86:3444-3451(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of two novel point mutations in the human protein S gene associated with familial protein S deficiency and thrombosis."Arterioscler. Thromb. Vasc. Biol. 16:1407-1415(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474."Blood 87:4643-4650(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V Leiden."Blood 88:1700-1707(1996) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis."Blood 88:4195-4204(1996) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies."J. Lab. Clin. Med. 128:218-227(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families."Thromb. Haemost. 75:437-444(1996) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of three novel mutations in hereditary protein S deficiency."Thromb. Haemost. 77:21-25(1997) [PubMed] [Europe PMC] [Abstract]
  25. "Protein S deficiency: a database of mutations."Thromb. Haemost. 77:1201-1214(1997) [PubMed] [Europe PMC] [Abstract]
  26. "Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency."Hum. Mutat. 14:30-39(1999) [PubMed] [Europe PMC] [Abstract]
  27. "Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene."Thromb. Haemost. 82:1634-1638(1999) [PubMed] [Europe PMC] [Abstract]
  28. "Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S."Blood 95:1935-1941(2000) [PubMed] [Europe PMC] [Abstract]
  29. "Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants."Hum. Mutat. 15:463-473(2000) [PubMed] [Europe PMC] [Abstract]
  30. "DNA sequence analysis of protein S deficiency -- identification of four point mutations in twelve Japanese subjects."Semin. Thromb. Hemost. 27:155-160(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families."Thromb. Haemost. 86:1392-1399(2001) [PubMed] [Europe PMC] [Abstract]
  32. "Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency."Blood 100:2812-2819(2002) [PubMed] [Europe PMC] [Abstract]
  33. "Genetic and phenotypic variability between families with hereditary protein S deficiency."Thromb. Haemost. 87:258-265(2002) [PubMed] [Europe PMC] [Abstract]
  34. "Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S."Thromb. Res. 105:233-239(2002) [PubMed] [Europe PMC] [Abstract]
  35. "Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations."Blood Coagul. Fibrinolysis 14:191-196(2003) [PubMed] [Europe PMC] [Abstract]
  36. "Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency."Br. J. Haematol. 126:219-225(2004) [PubMed] [Europe PMC] [Abstract]
  37. "Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study."Hum. Mutat. 25:259-269(2005) [PubMed] [Europe PMC] [Abstract]
  38. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  39. "Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene."Neonatology 98:337-340(2010) [PubMed] [Europe PMC] [Abstract]