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Glutathione S Transferase Alpha 2 (GSTa2)

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GST-A2; GST2; GSTA2-2; GTA2; GTH2

Glutathione S Transferase Alpha 2 (GSTa2)
CCC B957
HGNC 4627
MGI 95863
PubMed 19639209
RGD 2754
UniProt P09210
Wiki GSTA2

These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. Glutathione S-transferase A2 is a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB957Hu01 Recombinant Glutathione S Transferase Alpha 2 (GSTa2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB957Hu01 Polyclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) WB; IHC; ICC; IP.
MAB957Hu22 Monoclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) WB; IHC; ICC; IP.
LAB957Hu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) WB; IHC; ICC.
LAB957Hu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) WB; IHC; ICC; IF.
Assay Kits SEB957Hu ELISA Kit for Glutathione S Transferase Alpha 2 (GSTa2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB957Mu01 Recombinant Glutathione S Transferase Alpha 2 (GSTa2) Positive Control; Immunogen; SDS-PAGE; WB.
APB957Mu01 Active Glutathione S Transferase Alpha 2 (GSTa2) Cell culture; Activity Assays.
Antibodies PAB957Mu01 Polyclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Alpha 2 (GSTa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Alpha 2 (GSTa2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione S Transferase Alpha 2 (GSTa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione S Transferase Alpha 2 (GSTa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione S Transferase Alpha 2 (GSTa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Alpha 2 (GSTa2) ELISA Kit Customized Service Offer
  1. "The basic glutathione S-transferases from human livers are products of separate genes."Biochem. Biophys. Res. Commun. 145:474-481(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the human glutathione S-transferase A2 subunit gene."Arch. Biochem. Biophys. 298:747-752(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, sequencing and characterization of the human alpha glutathione S-transferase gene corresponding to the cDNA clone pGTH2."Biochem. J. 285:925-928(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver."Biochim. Biophys. Acta 1161:333-336(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other alpha class glutathione S-transferases."Biochem. J. 264:437-445(1989) [PubMed] [Europe PMC] [Abstract]
  8. "A surface mutant (G82R) of a human alpha-glutathione S-transferase shows decreased thermal stability and a new mode of molecular association in the crystal."Proteins 20:259-263(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases."J. Mol. Biol. 397:332-340(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Polymorphism of human alpha class glutathione transferases."Pharmacogenetics 11:609-617(2001) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]