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S100 Calcium Binding Protein A6 (S100A6)

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S100-A6; 2A9; 5B10; CABP; CACY; PRA; MLN 4; Calcyclin; Growth factor-inducible protein 2A9; Prolactin receptor-associated protein

S100 Calcium Binding Protein A6 (S100A6)
CCC B769
HGNC 10496
MGI 1339467
PubMed 12748257
RGD 620264
UniProt P06703
Wiki S100A6

Protein S100-A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Hu01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
APB769Hu01 Active S100 Calcium Binding Protein A6 (S100A6) Cell culture; Activity Assays.
Antibodies PAB769Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC/IF
MAB769Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; ICC/IF
LAB769Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
LAB769Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IF.
MAB769Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) IHC; ICC/IF
MAB769Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
MAB769Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
MAB769Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
MAB769Hu26 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
Assay Kits SEB769Hu ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Mu01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
RPB769Mu02 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Mu01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
LAB769Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB
LAB769Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IF.
PAB769Mu02 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
MAB769Mu21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) IHC
Assay Kits SEB769Mu ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Ra01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Ra01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC
LAB769Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) IHC
MAB769Ra21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits SEB769Ra ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Rb01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Rb51 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
LAB769Rb71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
PAB769Rb01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A6 (S100A6) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S100 Calcium Binding Protein A6 (S100A6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A6 (S100A6) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein."J. Biol. Chem. 261:12628-12632(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and functional analysis of a growth-regulated gene, the human calcyclin."J. Biol. Chem. 262:8325-8332(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum."J. Biol. Chem. 263:2397-2401(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Calcyclin and calvasculin exist in human platelets."Biochem. Biophys. Res. Commun. 189:1310-1316(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a cell cycle-dependent gene product as a sialic acid-binding protein."Biochem. Biophys. Res. Commun. 163:506-512(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins."J. Biol. Chem. 278:26923-26928(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope."J. Biol. Chem. 278:20210-20216(2003) [PubMed] [Europe PMC] [Abstract]
  10. "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility."Br. J. Cancer 101:1145-1154(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53."J. Mol. Biol. 394:922-930(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."FEBS Lett. 584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution."Structure 10:557-567(2002) [PubMed] [Europe PMC] [Abstract]