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S100 Calcium Binding Protein A6 (S100A6)

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S100-A6; 2A9; 5B10; CABP; CACY; PRA; MLN 4; Calcyclin; Growth factor-inducible protein 2A9; Prolactin receptor-associated protein

S100 Calcium Binding Protein A6 (S100A6)
CCC B769
HGNC 10496
MGI 1339467
PubMed 12748257
RGD 620264
UniProt P06703
Wiki S100A6

Protein S100-A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Hu01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
APB769Hu01 Active S100 Calcium Binding Protein A6 (S100A6) Cell culture; Activity Assays.
Antibodies PAB769Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB,IHC,ICC/IF
MAB769Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; ICC/IF
LAB769Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
LAB769Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IF.
MAB769Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) IHC; ICC/IF
MAB769Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
MAB769Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
MAB769Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
MAB769Hu26 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits SEB769Hu ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Mu01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
RPB769Mu02 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Mu01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
LAB769Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
LAB769Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IF.
PAB769Mu02 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
MAB769Mu21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits SEB769Mu ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Ra01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Ra01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB,IHC
LAB769Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
MAB769Ra21 Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits SEB769Ra ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB769Rb01 Recombinant S100 Calcium Binding Protein A6 (S100A6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB769Rb51 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
LAB769Rb71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC.
PAB769Rb01 Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A6 (S100A6) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S100 Calcium Binding Protein A6 (S100A6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S100 Calcium Binding Protein A6 (S100A6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A6 (S100A6) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A6 (S100A6) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein."J. Biol. Chem. 261:12628-12632(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and functional analysis of a growth-regulated gene, the human calcyclin."J. Biol. Chem. 262:8325-8332(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum."J. Biol. Chem. 263:2397-2401(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Calcyclin and calvasculin exist in human platelets."Biochem. Biophys. Res. Commun. 189:1310-1316(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a cell cycle-dependent gene product as a sialic acid-binding protein."Biochem. Biophys. Res. Commun. 163:506-512(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins."J. Biol. Chem. 278:26923-26928(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope."J. Biol. Chem. 278:20210-20216(2003) [PubMed] [Europe PMC] [Abstract]
  10. "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility."Br. J. Cancer 101:1145-1154(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53."J. Mol. Biol. 394:922-930(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."FEBS Lett. 584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution."Structure 10:557-567(2002) [PubMed] [Europe PMC] [Abstract]