≡

Permeability Glycoprotein (Pgp)

[Edit]

CD243; ABCB1; ABC20; CLCS; GP170; MDR1; PGY1; P-Glycoprotein; Multidrug resistance protein 1; ATP-Binding Cassette,Sub-Family B(MDR/TAP),Member 1; Colchicin Sensitivity

Permeability Glycoprotein (Pgp)
CCC B690
HGNC 40
MGI 97570
PubMed 16918323
RGD 619951
UniProt P08183
Wiki PGP

P-glycoprotein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Hu01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
RPB690Hu02 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
EPB690Hu61 Eukaryotic Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB690Hu01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
MAB690Hu22 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
LAB690Hu81 FITC-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IF.
PAB690Hu02 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
MAB690Hu21 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
MAB690Hu23 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
MAB690Hu24 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
Assay Kits SEB690Hu ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Mu02 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
RPB690Mu01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAB690Mu81 FITC-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IF.
LAB690Mu71 Biotin-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC.
PAB690Mu02 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
PAB690Mu01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
Assay Kits SEB690Mu ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Ra01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB690Ra01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
Assay Kits SEB690Ra ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells."Cell 47:381-389(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins."J. Biol. Chem. 265:506-514(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins."J. Biol. Chem. 272:5974-5982(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles."Biochem. Biophys. Res. Commun. 169:796-802(1990) [PubMed] [Europe PMC] [Abstract]
  7. "P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance."Biochem. Biophys. Res. Commun. 162:224-231(1989) [PubMed] [Europe PMC] [Abstract]
  8. "ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2."Pharmacogenomics 2:51-64(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function."Cancer Lett. 345:124-131(2014) [PubMed] [Europe PMC] [Abstract]
  13. "An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene."Cell 53:519-529(1988) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."Blood 91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
  15. "A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."Hum. Mutat. 15:486-486(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo."Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects."Clin. Pharmacol. Ther. 69:169-174(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)."Drug Metab. Pharmacokinet. 17:479-481(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone."Drug Metab. Pharmacokinet. 17:566-571(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
  21. "MDR1 Ala893 polymorphism is associated with inflammatory bowel disease."Am. J. Hum. Genet. 73:1282-1292(2003) [PubMed] [Europe PMC] [Abstract]
  22. ErratumAm. J. Hum. Genet. 74:1080-1080(2004)
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]