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Permeability Glycoprotein (Pgp)

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CD243; ABCB1; ABC20; CLCS; GP170; MDR1; PGY1; P-Glycoprotein; Multidrug resistance protein 1; ATP-Binding Cassette,Sub-Family B(MDR/TAP),Member 1; Colchicin Sensitivity

Permeability Glycoprotein (Pgp)
CCC B690
HGNC 40
MGI 97570
PubMed 16918323
RGD 619951
UniProt P08183
Wiki PGP

P-glycoprotein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Hu01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
RPB690Hu02 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
EPB690Hu61 Eukaryotic Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB690Hu01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) IHC
MAB690Hu22 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB
LAB690Hu81 FITC-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IF.
PAB690Hu02 Polyclonal Antibody to Permeability Glycoprotein (Pgp) IHC
MAB690Hu21 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB
MAB690Hu23 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB
MAB690Hu24 Monoclonal Antibody to Permeability Glycoprotein (Pgp) WB; ICC/IF
Assay Kits SEB690Hu ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Mu02 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
RPB690Mu01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAB690Mu81 FITC-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IF.
LAB690Mu71 Biotin-Linked Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC.
PAB690Mu02 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
PAB690Mu01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC; ICC; IP.
Assay Kits SEB690Mu ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB690Ra01 Recombinant Permeability Glycoprotein (Pgp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB690Ra01 Polyclonal Antibody to Permeability Glycoprotein (Pgp) WB; IHC
Assay Kits SEB690Ra ELISA Kit for Permeability Glycoprotein (Pgp) Enzyme-linked immunosorbent assay for Antigen Detection.
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  14. "Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."Blood 91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
  15. "A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."Hum. Mutat. 15:486-486(2000) [PubMed] [Europe PMC] [Abstract]
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  22. ErratumAm. J. Hum. Genet. 74:1080-1080(2004)
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