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Interferon Regulatory Factor 3 (IRF3)

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Interferon Regulatory Factor 3 (IRF3)
CCC B589
HGNC 6118
MGI 1859179
PubMed 12354379
RGD 1549774
UniProt Q14653
Wiki IRF3

Interferon regulatory factor 3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.

The IRF3 gene is present in a single copy in the human genome. Northern blot analysis detected a 1.6-kb constitutively expressed IRF3 transcript. The deduced 427-amino acid IRF3 protein is 34 to 40% identical to other members of the IRF family in the N-terminal region. Au et al. (1995) showed that IRF3 is a 50-kD protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB589Hu01 Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB589Hu01 Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP; FCM
MAB589Hu22 Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
Assay Kits SEB589Hu ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB589Mu01 Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB589Mu02 Recombinant Interferon Regulatory Factor 3 (IRF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB589Mu01 Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
PAB589Mu02 Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) WB; IHC; ICC; IP.
Assay Kits SEB589Mu ELISA Kit for Interferon Regulatory Factor 3 (IRF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 3 (IRF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 3 (IRF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 3 (IRF3) ELISA Kit Customized Service Offer
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  20. "VISA is an adapter protein required for virus-triggered IFN-beta Signaling."Mol. Cell 19:727-740(2005) [PubMed] [Europe PMC] [Abstract]
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  23. ErratumImmunity 25:849-849(2006)
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  29. "Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation."Mol. Cell. Biol. 33:2004-2015(2013) [PubMed] [Europe PMC] [Abstract]
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  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  33. "Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation."Nat. Struct. Biol. 10:913-921(2003) [PubMed] [Europe PMC] [Abstract]
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