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Secondary Lymphoid Tissue Chemokine (SLC)

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CCL21; 6Ckine; CKb9; ECL; SCYA21; TCA4; ECL; Chemokine(C-C-Motif)Ligand 21; Beta Chemokine Exodus-2; Efficient Chemoattractant For Lymphocytes

Secondary Lymphoid Tissue Chemokine (SLC)
CCC B575
HGNC 10620
MGI 1349183
PubMed 9670974
UniProt O00585
Wiki CCL21

Chemokine (C-C motif) ligand 21 (CCL21) is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB575Hu01 Recombinant Secondary Lymphoid Tissue Chemokine (SLC) Positive Control; Immunogen; SDS-PAGE; WB.
APB575Hu01 Active Secondary Lymphoid Tissue Chemokine (SLC) Cell culture; Activity Assays.
Antibodies PAB575Hu01 Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC; IP.
MAB575Hu22 Monoclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC; IP.
LAB575Hu71 Biotin-Linked Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC.
Assay Kits SEB575Hu ELISA Kit for Secondary Lymphoid Tissue Chemokine (SLC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB575Hu CLIA Kit for Secondary Lymphoid Tissue Chemokine (SLC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB575Mu01 Recombinant Secondary Lymphoid Tissue Chemokine (SLC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB575Mu02 Recombinant Secondary Lymphoid Tissue Chemokine (SLC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB575Mu01 Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC; IP.
PAB575Mu02 Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC; IP.
Assay Kits SEB575Mu ELISA Kit for Secondary Lymphoid Tissue Chemokine (SLC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB575Mu CLIA Kit for Secondary Lymphoid Tissue Chemokine (SLC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB575Ra01 Recombinant Secondary Lymphoid Tissue Chemokine (SLC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB575Ra01 Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Secondary Lymphoid Tissue Chemokine (SLC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Secondary Lymphoid Tissue Chemokine (SLC) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13."J. Biol. Chem. 272:19518-19524(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a novel beta chemokine containing six conserved cysteines."J. Immunol. 159:1589-1593(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."J. Immunol. 159:2554-2558(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7."J. Biol. Chem. 273:7118-7122(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of CCL21 and identification of a putative CCR7 binding site."Biochemistry 51:733-735(2012) [PubMed] [Europe PMC] [Abstract]