Serpin B3 (SERPINB3)
[Edit]SCCA1; T4-A; Serpin Peptidase Inhibitor,Clade B(ovalbumin),Member 3; Serpin B3
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Squamous cell carcinoma antigen (SCCA), a member of the serine protease inhibitor (serpin) family, is a subfraction of the tumor associated antigen TA-4, is a glycoprotein, with a molecular weight between 42 to 48 kDa.
Total SCCA in the circulation comprises 2 nearly identical, approximately 45 kDa proteins, SCCA1 and SCCA2. Both proteins are members of the high-molecular weight serine proteinase inhibitor (serpin) family with SCCA1 paradoxically inhibiting lysosomal cysteine proteinases and SCCA2 inhibiting chymotrypsin-like serine proteinases.
Although SCCA1 and SCCA2 are detected in the cytoplasm of normal squamous epithelial cells, neither serpin is detected normally in the serum.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB372Hu01 | Recombinant Serpin B3 (SERPINB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB372Hu02 | Recombinant Serpin B3 (SERPINB3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB372Hu61 | Eukaryotic Serpin B3 (SERPINB3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB372Hu03 | Recombinant Serpin B3 (SERPINB3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB372Hu01 | Polyclonal Antibody to Serpin B3 (SERPINB3) | WB,IHC |
| MAB372Hu22 | Monoclonal Antibody to Serpin B3 (SERPINB3) | WB | |
| PAB372Hu02 | Polyclonal Antibody to Serpin B3 (SERPINB3) | WB; IHC; ICC; IP. | |
| MAB372Hu21 | Monoclonal Antibody to Serpin B3 (SERPINB3) | WB | |
| MAB372Hu23 | Monoclonal Antibody to Serpin B3 (SERPINB3) | WB | |
| MAB372Hu24 | Monoclonal Antibody to Serpin B3 (SERPINB3) | WB; IHC | |
| PAB372Hu03 | Polyclonal Antibody to Serpin B3 (SERPINB3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB372Hu | ELISA Kit for Serpin B3 (SERPINB3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB372Hu | CLIA Kit for Serpin B3 (SERPINB3) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Serpin B3 (SERPINB3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Serpin B3 (SERPINB3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Serpin B3 (SERPINB3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Serpin B3 (SERPINB3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Serpin B3 (SERPINB3) | ELISA Kit Customized Service Offer |
- "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."Biochem. Biophys. Res. Commun. 181:51-58(1991) [PubMed] [Europe PMC] [Abstract]
- "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
- "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."J. Biol. Chem. 278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]