Serpin B3 (SERPINB3)

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SCCA1; T4-A; Serpin Peptidase Inhibitor,Clade B(ovalbumin),Member 3; Serpin B3

Serpin B3 (SERPINB3)

Squamous cell carcinoma antigen (SCCA), a member of the serine protease inhibitor (serpin) family, is a subfraction of the tumor associated antigen TA-4, is a glycoprotein, with a molecular weight between 42 to 48 kDa. 

Total SCCA in the circulation comprises 2 nearly identical, approximately 45 kDa proteins, SCCA1 and SCCA2. Both proteins are members of the high-molecular weight serine proteinase inhibitor (serpin) family with SCCA1 paradoxically inhibiting lysosomal cysteine proteinases and SCCA2 inhibiting chymotrypsin-like serine proteinases.

Although SCCA1 and SCCA2 are detected in the cytoplasm of normal squamous epithelial cells, neither serpin is detected normally in the serum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB372Hu01 Recombinant Serpin B3 (SERPINB3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB372Hu02 Recombinant Serpin B3 (SERPINB3) Positive Control; Immunogen; SDS-PAGE; WB.
EPB372Hu61 Eukaryotic Serpin B3 (SERPINB3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB372Hu03 Recombinant Serpin B3 (SERPINB3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB372Hu01 Polyclonal Antibody to Serpin B3 (SERPINB3) WB; IHC
MAB372Hu22 Monoclonal Antibody to Serpin B3 (SERPINB3) WB
PAB372Hu02 Polyclonal Antibody to Serpin B3 (SERPINB3) IHC
MAB372Hu21 Monoclonal Antibody to Serpin B3 (SERPINB3) WB
MAB372Hu23 Monoclonal Antibody to Serpin B3 (SERPINB3) WB
MAB372Hu24 Monoclonal Antibody to Serpin B3 (SERPINB3) WB; IHC
PAB372Hu03 Polyclonal Antibody to Serpin B3 (SERPINB3) WB; IHC; ICC; IP.
Assay Kits SEB372Hu ELISA Kit for Serpin B3 (SERPINB3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB372Hu CLIA Kit for Serpin B3 (SERPINB3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serpin B3 (SERPINB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serpin B3 (SERPINB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serpin B3 (SERPINB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serpin B3 (SERPINB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serpin B3 (SERPINB3) ELISA Kit Customized Service Offer
  1. "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."Biochem. Biophys. Res. Commun. 181:51-58(1991) [PubMed] [Europe PMC] [Abstract]
  2. "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."J. Biol. Chem. 278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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