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Angiotensin II Receptor 2 (AGTR2)

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AT2R; AT2-R; ATGR2; AT2; MRX88

Angiotensin II Receptor 2 (AGTR2)
CCC A973
HGNC 338
MGI 87966
PubMed 12089445
RGD 2072
UniProt P50052
Wiki AGTR2

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA973Hu01 Recombinant Angiotensin II Receptor 2 (AGTR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA973Hu01 Polyclonal Antibody to Angiotensin II Receptor 2 (AGTR2) WB; IHC; ICC; IP.
MAA973Hu22 Monoclonal Antibody to Angiotensin II Receptor 2 (AGTR2) WB; IHC; ICC; IP.
Assay Kits SEA973Hu ELISA Kit for Angiotensin II Receptor 2 (AGTR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Angiotensin II Receptor 2 (AGTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Angiotensin II Receptor 2 (AGTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Angiotensin II Receptor 2 (AGTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Angiotensin II Receptor 2 (AGTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiotensin II Receptor 2 (AGTR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA973Ra01 Recombinant Angiotensin II Receptor 2 (AGTR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA973Ra01 Polyclonal Antibody to Angiotensin II Receptor 2 (AGTR2) WB; IHC; ICC; IP.
MAA973Ra21 Monoclonal Antibody to Angiotensin II Receptor 2 (AGTR2) WB; IHC; ICC; IP.
Assay Kits SEA973Ra ELISA Kit for Angiotensin II Receptor 2 (AGTR2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The sequence and genomic organization of the human type 2 angiotensin II receptor."Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization."Genomics 25:601-603(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung."Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor."Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of the human angiotensin II type 2 receptor cDNA."Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues."Recept. Channels 2:271-280(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "AGTR2 mutations in X-linked mental retardation."Science 296:2401-2403(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
  12. "XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing."Am. J. Hum. Genet. 93:368-383(2013) [PubMed] [Europe PMC] [Abstract]