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Cystatin C (Cys-C)

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CST3; Cystatin 3; Gamma Trace; Post-Gamma-Globulin; Neuroendocrine Basic Polypeptide; Amyloid Angiopathy And Cerebral Hemorrhage

Cystatin C (Cys-C)
CCC A896
HGNC 2475
MGI 102519
PubMed 18295055
RGD 2432
UniProt P01034
Wiki Cystatin_3

Cystatin C: A serum protein that is filtered out of the blood by the kidneys and that serves as a measure of kidney function. Cystatin C is produced steadily by all types of nucleated cells in the body. Its low molecular mass allows it to be freely filtered by the glomerular membrane in the kidney.

Its concentration in blood correlates with the glomerular filtration rate. The levels of cystatin C are independent of weight and height, muscle mass, age (over a year of age), and sex. Measurements can be made and interpreted from a single random sample. Cystatin C is a better marker of the glomerular filtration rate and hence of kidney function than creatinine which was the most commonly used measure of kidney function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Hu01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
EPA896Hu61 Eukaryotic Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
APA896Hu61 Active Cystatin C (Cys-C) Cell culture; Activity Assays.
Antibodies PAA896Hu01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
MAA896Hu21 Monoclonal Antibody to Cystatin C (Cys-C) WB,IHC
MAA896Hu22 Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC
LAA896Hu71 Biotin-Linked Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
MAA896Hu24 Monoclonal Antibody to Cystatin C (Cys-C) WB,IHC
LAA896Hu74 Biotin-Linked Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
MAA896Hu26 Monoclonal Antibody to Cystatin C (Cys-C) WB
LAA896Hu76 Biotin-Linked Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
MAA896Hu25 Monoclonal Antibody to Cystatin C (Cys-C) WB
MAA896Hu23 Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
MAA896Hu27 Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
Assay Kits SEA896Hu ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA896Hu CLIA Kit for Cystatin C (Cys-C) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Mu01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
RPA896Mu02 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Mu01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
PAA896Mu02 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
Assay Kits SEA896Mu ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Ra01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
APA896Ra61 Active Cystatin C (Cys-C) Cell culture; Activity Assays.
EPA896Ra61 Eukaryotic Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Ra01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
MAA896Ra21 Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
LAA896Ra71 Biotin-Linked Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
Assay Kits SEA896Ra ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cystatin C (Cys-C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cystatin C (Cys-C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cystatin C (Cys-C) Polyclonal Antibody Customized Service Offer
Assay Kits SEA896Rb ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Ca01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Ca01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
Assay Kits SEA896Ca ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Po01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Po01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
MAA896Po21 Monoclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
Assay Kits SEA896Po ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Bo01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Bo01 Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IP.
LAA896Bo71 Biotin-Linked Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
LAA896Bo81 FITC-Linked Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC; IF.
Assay Kits SEA896Bo ELISA Kit for Cystatin C (Cys-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA896Ga01 Recombinant Cystatin C (Cys-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA896Ga01 Polyclonal Antibody to Cystatin C (Cys-C) WB
LAA896Ga71 Biotin-Linked Polyclonal Antibody to Cystatin C (Cys-C) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cystatin C (Cys-C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cystatin C (Cys-C) ELISA Kit Customized Service Offer
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  9. "Human cystatin, a new protein inhibitor of cysteine proteinases."Biochem. Biophys. Res. Commun. 118:103-109(1984) [PubMed] [Europe PMC] [Abstract]
  10. "Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white."Hoppe-Seyler's Z. Physiol. Chem. 364:1487-1496(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The disulphide bridges of human cystatin C (gamma-trace) and chicken cystatin."FEBS Lett. 170:370-374(1984)
  13. "Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease."Proteomics 4:2229-2233(2004) [PubMed] [Europe PMC] [Abstract]
  14. "A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility."Exp. Eye Res. 84:1135-1139(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry."J. Am. Soc. Mass Spectrom. 21:908-917(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping."Nat. Struct. Biol. 8:316-320(2001) [PubMed] [Europe PMC] [Abstract]
  20. "3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets."Proteins 61:570-578(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis."Hum. Genet. 89:377-380(1992) [PubMed] [Europe PMC] [Abstract]
  22. "CST3 genotype associated with exudative age related macular degeneration."Br. J. Ophthalmol. 86:214-219(2002) [PubMed] [Europe PMC] [Abstract]