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Parathyroid hormone is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body: PTH half-life is approximately 4 minutes. It has a molecular mass of 9.4 kDa.
PTH was one of the first hormones to be shown to use the G-protein, adenylyl cyclase second messenger system.Normal total plasma calcium level ranges from 8.5 to 10.2 mg/dL (2.12 mmol/L to 2.55 mmol/L).
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Mu01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA866Mu02 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA866Mu01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| PAA866Mu02 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA866Mu | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Ra01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPA866Ra11 | BSA Conjugated Parathyroid Hormone (PTH) | Immunogen; SDS-PAGE; WB. | |
| CPA866Ra21 | OVA Conjugated Parathyroid Hormone (PTH) | Immunogen; SDS-PAGE; WB. | |
| APA866Ra01 | Active Parathyroid Hormone (PTH) | Cell culture; Activity Assays. | |
| Antibodies | PAA866Ra01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| MAA866Ra21 | Monoclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| PAA866Ra08 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| PAA866Mi08 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA866Ra | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CCA866Ra | CLIA Kit for Parathyroid Hormone (PTH) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Parathyroid Hormone (PTH) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Parathyroid Hormone (PTH) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Parathyroid Hormone (PTH) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | CEA866Rb | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Ca01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA866Ca02 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA866Ca03 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA866Ca01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| MAA866Ca21 | Monoclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA866Ca | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Po01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA866Po01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| LAA866Po81 | FITC-Linked Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IF. | |
| LAA866Po71 | Biotin-Linked Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC. | |
| MAA866Po21 | Monoclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA866Po | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Bo01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPA866Bo11 | BSA Conjugated Parathyroid Hormone (PTH) | Immunogen; SDS-PAGE; WB. | |
| CPA866Bo21 | OVA Conjugated Parathyroid Hormone (PTH) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA866Bo01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| PAA866Bo08 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA866Bo | ELISA Kit for Parathyroid Hormone (PTH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA866Ga01 | Recombinant Parathyroid Hormone (PTH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA866Ga01 | Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IP. |
| LAA866Ga71 | Biotin-Linked Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC. | |
| LAA866Ga81 | FITC-Linked Polyclonal Antibody to Parathyroid Hormone (PTH) | WB; IHC; ICC; IF. | |
| Assay Kits | n/a | CLIA Kit for Parathyroid Hormone (PTH) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Parathyroid Hormone (PTH) | ELISA Kit Customized Service Offer |
- "Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone."Proc. Natl. Acad. Sci. U.S.A. 78:7365-7369(1981) [PubMed] [Europe PMC] [Abstract]
- "Nucleotide sequence of the human parathyroid hormone gene."Proc. Natl. Acad. Sci. U.S.A. 80:2127-2131(1983) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Inefficient membrane targeting, translocation, and proteolytic processing by signal peptidase of a mutant preproparathyroid hormone protein."J. Biol. Chem. 270:1629-1635(1995) [PubMed] [Europe PMC] [Abstract]
- "Structural analysis of human proparathyroid hormone by a new microsequencing approach."Nature 249:155-157(1974) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "The amino-acid sequence of the amino-terminal 37 residues of human parathyroid hormone."Proc. Natl. Acad. Sci. U.S.A. 71:384-388(1974) [PubMed] [Europe PMC] [Abstract]
- "Complete amino acid sequence of human parathyroid hormone."Biochemistry 17:5723-5729(1978) [PubMed] [Europe PMC] [Abstract]
- (In) Talmadge R.V., Owen M., Parsons J.A. (eds.);Calcium-regulating hormones, pp.9-14, Excerpta Medica Foundation, Amsterdam (1975)
- "A reinvestigation of the amino-terminal sequence of human parathyroid hormone."Biochemistry 14:1842-1847(1975) [PubMed] [Europe PMC] [Abstract]
- "Solid-phase synthesis of the biologically active N-terminal 1-34 peptide of human parathyroid hormone."Hoppe-Seyler's Z. Physiol. Chem. 355:415-421(1974) [PubMed] [Europe PMC] [Abstract]
- "Synthesis of sequence 1-34 of human parathyroid hormone."Helv. Chim. Acta 56:470-473(1973) [PubMed] [Europe PMC] [Abstract]
- "Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I."Mol. Cell. Biochem. 348:33-42(2011) [PubMed] [Europe PMC] [Abstract]
- "Investigation of the solution structure of the human parathyroid hormone fragment (1-34) by 1H NMR spectroscopy, distance geometry, and molecular dynamics calculations."Biochemistry 30:6936-6942(1991) [PubMed] [Europe PMC] [Abstract]
- "Stabilized NMR structure of human parathyroid hormone(1-34)."Eur. J. Biochem. 215:315-321(1993) [PubMed] [Europe PMC] [Abstract]
- "Structure of human parathyroid hormone 1-37 in solution."J. Biol. Chem. 270:15194-15202(1995) [PubMed] [Europe PMC] [Abstract]
- "Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)."Biochem. Biophys. Res. Commun. 267:213-220(2000) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution."J. Biol. Chem. 275:27238-27244(2000) [PubMed] [Europe PMC] [Abstract]
- "Molecular recognition of parathyroid hormone by its G protein-coupled receptor."Proc. Natl. Acad. Sci. U.S.A. 105:5034-5039(2008) [PubMed] [Europe PMC] [Abstract]
- "Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism."J. Clin. Invest. 86:1084-1087(1990) [PubMed] [Europe PMC] [Abstract]
- "A novel mutation of the signal peptide of the preproparathyroid hormone gene associated with autosomal recessive familial isolated hypoparathyroidism."J. Clin. Endocrinol. Metab. 84:3792-3796(1999) [PubMed] [Europe PMC] [Abstract]
- "Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone."Proc. Natl. Acad. Sci. U.S.A. 104:19989-19994(2007) [PubMed] [Europe PMC] [Abstract]