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Nischarin (NISCH)

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IRAS; Imidazoline Receptor Candidate; I-1 Receptor Candidate Protein; Imidazoline Receptor Antisera Selected; Imidazoline receptor antisera-selected protein

Nischarin (NISCH)
CCC A249
HGNC 18006
MGI 1928323
PubMed 11121431
RGD 1306950
UniProt Q9Y2I1
Wiki NISCH
Nischarin acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA249Hu01 Recombinant Nischarin (NISCH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA249Hu01 Polyclonal Antibody to Nischarin (NISCH) WB; IHC; ICC; IP.
MAA249Hu22 Monoclonal Antibody to Nischarin (NISCH) WB; IHC; ICC; IP.
Assay Kits SEA249Hu ELISA Kit for Nischarin (NISCH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA249Mu01 Recombinant Nischarin (NISCH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA249Mu01 Polyclonal Antibody to Nischarin (NISCH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nischarin (NISCH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nischarin (NISCH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nischarin (NISCH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nischarin (NISCH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nischarin (NISCH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nischarin (NISCH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nischarin (NISCH) ELISA Kit Customized Service Offer
  1. "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization."DNA Cell Biol. 19:319-329(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IRAS splice variants."Ann. N. Y. Acad. Sci. 1009:419-426(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera."J. Auton. Nerv. Syst. 72:98-110(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Insulin receptor substrate 4 associates with the protein IRAS."J. Biol. Chem. 277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]
  10. "IRAS is an anti-apoptotic protein."Ann. N. Y. Acad. Sci. 1009:400-412(2003) [PubMed] [Europe PMC] [Abstract]
  11. "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells."Cell Death Differ. 10:933-935(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region."J. Biol. Chem. 279:54770-54782(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells."J. Biol. Chem. 288:15495-15509(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of nischarin PX-domain."Submitted (OCT-2010) to the PDB data bank