S100 Calcium Binding Protein (S100)

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S100-A1; S100A1; S100-Alpha; S-100 Protein; S-100 protein subunit alpha; S-100 protein alpha chain

S100 Calcium Binding Protein (S100)
A1is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation.
Reduced expression of this protein has been implicated in cardiomyopathies. S100A1 overexpression enhances cardiac contractile performance which suggests that S100A1 is a regulator of myocardial contractility. S100A1 improves cardiac performance both by regulating calcium ion handling by the sarcoplasmic reticulum and the responsiveness of myofibrils to calcium ion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA012Hu01 Recombinant S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
EPA012Hu61 Eukaryotic S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
APA012Hu61 Active S100 Calcium Binding Protein (S100) Cell culture; Activity Assays.
APA012Hu01 Active S100 Calcium Binding Protein (S100) Cell culture; Activity Assays.
Antibodies PAA012Hu01 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu22 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
LAA012Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC.
LAA012Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IF.
MAA012Hu21 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu23 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu24 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu27 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu25 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
PAA012Hu02 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Hu29 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
Assay Kits SEA012Hu ELISA Kit for S100 Calcium Binding Protein (S100) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA012Hu CLIA Kit for S100 Calcium Binding Protein (S100) Chemiluminescent immunoassay for Antigen Detection.
AEA012Hu ELISA Kit for Anti-S100 Calcium Binding Protein Antibody (Anti-S100) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA012Mu01 Recombinant S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
RPA012Mu02 Recombinant S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA012Mu01 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
LAA012Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC.
PAA012Mu02 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
Assay Kits SEA012Mu ELISA Kit for S100 Calcium Binding Protein (S100) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA012Ra01 Recombinant S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
APA012Ra01 Active S100 Calcium Binding Protein (S100) Cell culture; Activity Assays.
Antibodies PAA012Ra01 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
LAA012Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC.
LAA012Ra81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IF.
MAA012Ra21 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Ra22 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Ra23 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
Assay Kits SEA012Ra ELISA Kit for S100 Calcium Binding Protein (S100) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S100 Calcium Binding Protein (S100) Recombinant Protein Customized Service Offer
Antibodies PAA012Po01 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein (S100) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein (S100) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA012Bo01 Recombinant S100 Calcium Binding Protein (S100) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA012Bo01 Polyclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
MAA012Bo21 Monoclonal Antibody to S100 Calcium Binding Protein (S100) WB; IHC; ICC; IP.
Assay Kits SEA012Bo ELISA Kit for S100 Calcium Binding Protein (S100) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S100 Calcium Binding Protein (S100) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S100 Calcium Binding Protein (S100) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S100 Calcium Binding Protein (S100) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein (S100) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein (S100) ELISA Kit Customized Service Offer
  1. "S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart."Biochemistry 31:10258-10264(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Heterodimeric interaction and interfaces of S100A1 and S100P."Biochem. J. 382:375-383(2004) [PubMed] [Europe PMC] [Abstract]
  8. "S100A1 and calmodulin compete for the same binding site on ryanodine receptor."J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]
  9. "S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."FEBS Lett. 584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Solution NMR structure and dynamics of human apo-S100A1 protein."J. Struct. Biol. 174:391-399(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Post-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein."J. Biol. Chem. 287:40457-40470(2012) [PubMed] [Europe PMC] [Abstract]