S100 Calcium Binding Protein (S100)
[Edit]S100-A1; S100A1; S100-Alpha; S-100 Protein; S-100 protein subunit alpha; S-100 protein alpha chain
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A1is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation.
Reduced expression of this protein has been implicated in cardiomyopathies. S100A1 overexpression enhances cardiac contractile performance which suggests that S100A1 is a regulator of myocardial contractility. S100A1 improves cardiac performance both by regulating calcium ion handling by the sarcoplasmic reticulum and the responsiveness of myofibrils to calcium ion.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA012Mu01 | Recombinant S100 Calcium Binding Protein (S100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA012Mu02 | Recombinant S100 Calcium Binding Protein (S100) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA012Mu01 | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC/IF |
| LAA012Mu71 | Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC. | |
| PAA012Mu02 | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA012Mu | ELISA Kit for S100 Calcium Binding Protein (S100) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA012Ra01 | Recombinant S100 Calcium Binding Protein (S100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA012Ra01 | Active S100 Calcium Binding Protein (S100) | Cell culture; Activity Assays. | |
| Antibodies | PAA012Ra01 | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. |
| LAA012Ra71 | Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC. | |
| LAA012Ra81 | FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IF. | |
| MAA012Ra21 | Monoclonal Antibody to S100 Calcium Binding Protein (S100) | WB | |
| MAA012Ra22 | Monoclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. | |
| MAA012Ra23 | Monoclonal Antibody to S100 Calcium Binding Protein (S100) | IHC | |
| Assay Kits | SEA012Ra | ELISA Kit for S100 Calcium Binding Protein (S100) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant S100 Calcium Binding Protein (S100) | Recombinant Protein Customized Service Offer |
| Antibodies | PAA012Po01 | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for S100 Calcium Binding Protein (S100) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for S100 Calcium Binding Protein (S100) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA012Bo01 | Recombinant S100 Calcium Binding Protein (S100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA012Bo01 | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. |
| MAA012Bo21 | Monoclonal Antibody to S100 Calcium Binding Protein (S100) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA012Bo | ELISA Kit for S100 Calcium Binding Protein (S100) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant S100 Calcium Binding Protein (S100) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to S100 Calcium Binding Protein (S100) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to S100 Calcium Binding Protein (S100) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for S100 Calcium Binding Protein (S100) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for S100 Calcium Binding Protein (S100) | ELISA Kit Customized Service Offer |
- "S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart."Biochemistry 31:10258-10264(1992) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
- "Heterodimeric interaction and interfaces of S100A1 and S100P."Biochem. J. 382:375-383(2004) [PubMed] [Europe PMC] [Abstract]
- "S100A1 and calmodulin compete for the same binding site on ryanodine receptor."J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]
- "S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."FEBS Lett. 584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
- "Solution NMR structure and dynamics of human apo-S100A1 protein."J. Struct. Biol. 174:391-399(2011) [PubMed] [Europe PMC] [Abstract]
- "Post-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein."J. Biol. Chem. 287:40457-40470(2012) [PubMed] [Europe PMC] [Abstract]