Thrombosis- localized clotting of the blood -can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs. 1. Circadian nuclear receptor Rev-erbα is e......2023-01-09

On December 14, 2022, Zhenyu Zhong, Department of Immunology, University of Texas Southwestern Medical Center, USA, and his team published a paper titled “Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development” in Immunity. They fdemonstrated that impaired TREM2-dependent efferocytosis is a previously unrecognized key pathogenic event that licenses chronic liver inflammation to ultimately drive simple steatosis transition to nonalcoholic steatohepatitis (NASH).The kits [ELISA Kit for Sphingosine-1-Phosphate (S1P), CEG031Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserche......2023-01-06

Crohn’s disease is a chronic inflammatory condition that affects the gastrointestinal tract. It can cause lesions from mouth to anus and may result in extraintestinal complications.Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses. Thetherapies generally consist of steroids for rapid palliation of symptoms,monoclonal antibodies to IL-12/23 or integrin α4β7, immunomodulators, combination therapies, or surgery. However, these therapies may cause adverse reactions and have limited efficacy.Further exploration of the pathogenesis of Cro......2022-12-30

On October 24, 2022,Bo Peng, Department of Neurosurgery, Huashan Hospital, Fudan University, China, and his team published a paper titled “Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice” in Nature Communications. They elucidated the cellular and molecular mechanisms of microglial debris removal in mice, extending the knowledge on the maintenance of CNS homeostasis.The proteins [Recombinant Complement C4-B (C4B), RPB305Mu01; Recombinant Complement Component 4a (C4a), RPA389Mu01; Recombinant Complement Component 1, Q Subcomponent A (C1qA), RPD207Mu01; Recombinant Complement Component 3 (C3)......2022-12-30

Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli.Innate immune responses involving sensing of microbes and generation of antimicrobial effectors are the primary defense in response to pathogenic attacks and damage signals. Accumulating evidence suggests that multilayered molecular crosstalk between innate immune signaling and ......2022-12-26

On November 7, 2022,Shiming Yang, Department of Gastroenterology, Xinqiao Hospital, Army Medical University, China, and his team published a paper titled “Endoscopy Deliverable and Mushroom-Cap-Inspired Hyperboloid-Shaped Drug-Laden Bioadhesive Hydrogel for Stomach Perforation Repair” in ACS Nano. They demonstrated that the compressible hyperboloid-shaped gel could stably block the perforation and promoted wound healing during the 28 days of observation.The antibodies[Polyclonal Antibodyto Proliferating Cell Nuclear Antigen (PCNA), PAA591Mi01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Gastrointestinal tract perforation is a full......2022-12-22