Acute kidney injury (AKI) is a global health problem,whichaffects about 20% of hospital inpatients. The primary clinical causes of AKI consist of sepsis, and nephrotoxic medications, ischemia-reperfusion injury. Current therapies for AKI are supportive, and short-term mortality remains high. In those who survive an episode of AKI, 30% are left with chronic kidney disease (CKD). The remaining 70% that recover full kidney function are at about 28-fold increased risk of ultimately developing CKD. Both AKI and CKD are strongly and independently associated with incident cardiovascular disease, and together, these exert a substantial global socioeconomic burden. Recently, a number of literat......2023-02-14

On January 12, 2023,Xiangming Fang, Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, Zhejiang University School of Medicine, China, and his team published a paper titled “TREM2hiresident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis” in Nature Metabolism. Their findings suggest that the modulation of TREM2hicardiac-resident macrophages could serve as a therapeutic strategy for SICM.The kits [ELISA Kit for Atrial Natriuretic Peptide (ANP), SEA225Mu; ELISA Kit for N-Terminal Pro-Brain Natriuretic Peptide (NT-ProBNP), SEA485Mu; ELISA Kit for Cardiac Troponin I (cTnI), SEA478Mu] of Cloud-Clone brand was chosed in this artic......2023-02-09

As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease.Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings. Harmonious cell-cell communication involving microglia are considered crucial to maintain the healthy state of the tissue environment and to overcome pathology such as neuroinflammation. Analyses of such intercellular pathways have contributed to our understanding of the heterogeneous but context-associated microglial responses to e......2023-02-08

On January 19, 2023,Tian Xue, CAS Key Laboratory of Brain Function and Disease, China, and his team published a paper titled “Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis” inCell. Their work unveiled a retina-supraoptic nucleus-brown adipose tissue axis that mediates the effect of light on glucose metabolism.The kits [ELISA Kit for Cholecystokinin (CCK), CEA802Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Public health studies indicate that artificial light is a high-risk factor for metabolic disorders. However, the neural mechanism underlying metabolic modulation by light remains elusive......2023-02-02

Acquired immunodeficiency syndrome (AIDS) is an infectious disease caused by human immunodeficiency virus (HIV) infection, which seriously endangers people’s health and lives. At present, the clinical treatment for AIDS is antiretroviral therapy (ART), which minimizes viral replication in patients and reduces plasma viral load to a level that cannot be detected by conventional testing methods. However, once the treatment is stopped, viral load will rebound to the pre-treatment level. An important reason why HIV is difficult to eliminate from the body is the long-term existence of HIV latent reservoir. The HIV latent virus reservoir composed of latently infected cells is a huge obstac......2023-01-16

On December 1, 2022, Teunis B. H. Geijtenbeek, Department of Experimental Immunology, Amsterdam UMC - location AMC, University of Amsterdam, The Netherlands, and his team published a paper titled “Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs” in nature immunology. They demonstrated that dectin-1 signaling in human DCs specifically instructed the differentiation of non-pathogenic IFN-γ-TH17 cells.The kits [ELISA Kit for Interferon Regulatory Factor 1 (IRF1), SEB564Hu; ELISA Kit for Interferon Regulatory Factor 5 (IRF5), SEB598Hu] of Cloud-Clone brand was chosed in this article, we are so proud fo......2023-01-10